Transthyretin amyloidosis

Merrill Benson, Tomoyuki Uemichi

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

A tremendous amount of progress has been made in the study of the transthyretin amyloidoses. To date the most visible element of this progress has been the discovery and description of new transthyretin mutations and the disease they cause. This has been essentially descriptive research, but that is not so bad. The generation of descriptive data has formed the basis for more in-depth research on transthyretin amyloidosis, has resulted in the discovery of apolipoprotein AI, gelsolin, fibrinogen α chain, and lysozyme forms of hereditary amyloidosis and allowed patients afflicted with these diseases to benefit from diagnostic testing, genetic counseling, prenatal testing, and treatment such as liver transplantation. Now we are charged with the task of taking our knowledge base and pursuing mechanistic research into pathogenesis. This hopefully will lead to means to prevent or cure these diseases.

Original languageEnglish
Pages (from-to)44-56
Number of pages13
JournalAmyloid
Volume3
Issue number1
StatePublished - 1996

Fingerprint

Familial Amyloidosis
Research
Gelsolin
Prealbumin
Knowledge Bases
Apolipoprotein A-I
Genetic Counseling
Muramidase
Liver Transplantation
Fibrinogen
Mutation
Amyloidosis, Hereditary, Transthyretin-Related
Therapeutics

Keywords

  • Amyloidosis
  • Cardiomyopathy
  • Hereditary
  • Neuropathy
  • Transthyretin

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Benson, M., & Uemichi, T. (1996). Transthyretin amyloidosis. Amyloid, 3(1), 44-56.

Transthyretin amyloidosis. / Benson, Merrill; Uemichi, Tomoyuki.

In: Amyloid, Vol. 3, No. 1, 1996, p. 44-56.

Research output: Contribution to journalArticle

Benson, M & Uemichi, T 1996, 'Transthyretin amyloidosis', Amyloid, vol. 3, no. 1, pp. 44-56.
Benson M, Uemichi T. Transthyretin amyloidosis. Amyloid. 1996;3(1):44-56.
Benson, Merrill ; Uemichi, Tomoyuki. / Transthyretin amyloidosis. In: Amyloid. 1996 ; Vol. 3, No. 1. pp. 44-56.
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