Transurethral high intensity focused ultrasound: Catheter based prototypes and experimental results

Ralf Seip, Mihir Biswas, Maksim Kuznetsov, Narendra T. Sanghvi, Thomas Gardner, Noshir F. Dabhoiwala

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Transurethral catheters containing multiple high-intensity focused ultrasound (HIFU) transducers at their tip have been designed, built and tested for the treatment of prostate tissue. These catheters address a need in the medical community for simple, fast, and effective treatments using low-cost, disposable, and application-specific devices for disease control through tissue ablation. The HIFU transducers used in the transurethral catheter prototypes have a focal length of 10 mm, operate at 5 MHz, and are able to generate total acoustic power levels exceeding 8 Watts. Experimental in vitro and in vivo results show that the catheters can ablate cylindrical tissue volumes > 5 cm3 around the urethra in less than 15 minutes through simple catheter rotation. These results indicate that catheter-based HIFU transducers can be used to provide a viable alternative to current minimally-invasive therapies for prostate diseases, such as BPH. The technologies also show promise for the treatment of other diseases that would benefit from using small, minimally invasive HIFU transducers (such as esophageal, thoracic, and ear/nose/throat and OB/Gyn applications). Catheter prototypes are described, and in vitro, in vivo, and histology data are presented.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
EditorsS.C. Schneider, M. Levy, B.R. McAvoy
Pages1413-1416
Number of pages4
Volume2
StatePublished - 2000
Event2000 IEEE Ultrasonics Symposium - San Juan, Puerto Rico
Duration: Oct 22 2000Oct 25 2000

Other

Other2000 IEEE Ultrasonics Symposium
CountryPuerto Rico
CitySan Juan
Period10/22/0010/25/00

Fingerprint

Catheters
Ultrasonics
Transducers
Tissue
Disease control
Histology
Ablation
Acoustics
Costs

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Seip, R., Biswas, M., Kuznetsov, M., Sanghvi, N. T., Gardner, T., & Dabhoiwala, N. F. (2000). Transurethral high intensity focused ultrasound: Catheter based prototypes and experimental results. In S. C. Schneider, M. Levy, & B. R. McAvoy (Eds.), Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1413-1416)

Transurethral high intensity focused ultrasound : Catheter based prototypes and experimental results. / Seip, Ralf; Biswas, Mihir; Kuznetsov, Maksim; Sanghvi, Narendra T.; Gardner, Thomas; Dabhoiwala, Noshir F.

Proceedings of the IEEE Ultrasonics Symposium. ed. / S.C. Schneider; M. Levy; B.R. McAvoy. Vol. 2 2000. p. 1413-1416.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Seip, R, Biswas, M, Kuznetsov, M, Sanghvi, NT, Gardner, T & Dabhoiwala, NF 2000, Transurethral high intensity focused ultrasound: Catheter based prototypes and experimental results. in SC Schneider, M Levy & BR McAvoy (eds), Proceedings of the IEEE Ultrasonics Symposium. vol. 2, pp. 1413-1416, 2000 IEEE Ultrasonics Symposium, San Juan, Puerto Rico, 10/22/00.
Seip R, Biswas M, Kuznetsov M, Sanghvi NT, Gardner T, Dabhoiwala NF. Transurethral high intensity focused ultrasound: Catheter based prototypes and experimental results. In Schneider SC, Levy M, McAvoy BR, editors, Proceedings of the IEEE Ultrasonics Symposium. Vol. 2. 2000. p. 1413-1416
Seip, Ralf ; Biswas, Mihir ; Kuznetsov, Maksim ; Sanghvi, Narendra T. ; Gardner, Thomas ; Dabhoiwala, Noshir F. / Transurethral high intensity focused ultrasound : Catheter based prototypes and experimental results. Proceedings of the IEEE Ultrasonics Symposium. editor / S.C. Schneider ; M. Levy ; B.R. McAvoy. Vol. 2 2000. pp. 1413-1416
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