Traumatic Brain Injury-Practice Based Evidence Study: Design and Patients, Centers, Treatments, and Outcomes

Susan D. Horn, John D. Corrigan, Jennifer Bogner, Flora Hammond, Ronald T. Seel, Randall J. Smout, Ryan S. Barrett, Marcel P. Dijkers, Gale G. Whiteneck

Research output: Contribution to journalArticle

35 Scopus citations


MAIN OUTCOME MEASURES: Return to acute care during rehabilitation, rehabilitation length of stay, FIM at discharge, residence at discharge, and 9 months postdischarge rehospitalization, FIM, participation, and subjective well-being.

OBJECTIVES: To describe study design, patients, centers, treatments, and outcomes of a traumatic brain injury (TBI) practice-based evidence (PBE) study and to evaluate the generalizability of the findings to the U.S. TBI inpatient rehabilitation population.

DESIGN: Prospective, longitudinal, observational study.

SETTING: Ten inpatient rehabilitation centers.

PARTICIPANTS: Patients (N=2130) enrolled between October 2008 and September 2011 and admitted for inpatient rehabilitation after an index TBI injury.

INTERVENTIONS: Not applicable.

RESULTS: The level of admission FIM cognitive score was found to create relatively homogeneous subgroups for the subsequent analysis of best treatment combinations. There were significant differences in patient and injury characteristics, treatments, rehabilitation course, and outcomes by admission FIM cognitive subgroups. TBI-PBE study patients were overall similar to U.S. national TBI inpatient rehabilitation populations.

CONCLUSIONS: This TBI-PBE study succeeded in capturing naturally occurring variation in patients and treatments, offering opportunities to study best treatments for specific patient impairments. Subsequent articles in this issue report differences between patients and treatments and associations with outcomes in greater detail.

Original languageEnglish (US)
Pages (from-to)S178-S96.
JournalArchives of Physical Medicine and Rehabilitation
Issue number8
StatePublished - Aug 1 2015



  • Brain injuries
  • Comparative effectiveness research
  • Rehabilitation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Horn, S. D., Corrigan, J. D., Bogner, J., Hammond, F., Seel, R. T., Smout, R. J., Barrett, R. S., Dijkers, M. P., & Whiteneck, G. G. (2015). Traumatic Brain Injury-Practice Based Evidence Study: Design and Patients, Centers, Treatments, and Outcomes. Archives of Physical Medicine and Rehabilitation, 96(8), S178-S96..