Traumatic Brain Injury Severity Affects Neurogenesis in Adult Mouse Hippocampus

Xiaoting Wang, Xiang Gao, Stephanie Michalski, Shu Zhao, Jinhui Chen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) has been proven to enhance neural stem cell (NSC) proliferation in the hippocampal dentate gyrus. However, various groups have reported contradictory results on whether TBI increases neurogenesis, partially due to a wide range in the severities of injuries seen with different TBI models. To address whether the severity of TBI affects neurogenesis in the injured brain, we assessed neurogenesis in mouse brains receiving different severities of controlled cortical impact (CCI) with the same injury device. The mice were subjected to mild, moderate, or severe TBI by a CCI device. The effects of TBI severity on neurogenesis were evaluated at three stages: NSC proliferation, immature neurons, and newly-generated mature neurons. The results showed that mild TBI did not affect neurogenesis at any of the three stages. Moderate TBI promoted NSC proliferation without increasing neurogenesis. Severe TBI increased neurogenesis at all three stages. Our data suggest that the severity of injury affects adult neurogenesis in the hippocampus, and thus it may partially explain the inconsistent results of different groups regarding neurogenesis following TBI. Further understanding the mechanism of TBI-induced neurogenesis may provide a potential approach for using endogenous NSCs to protect against neuronal loss after trauma.

Original languageEnglish (US)
Pages (from-to)721-733
Number of pages13
JournalJournal of Neurotrauma
Volume33
Issue number8
DOIs
StatePublished - Apr 15 2016

Fingerprint

Neurogenesis
Hippocampus
Neural Stem Cells
Cell Proliferation
Wounds and Injuries
Brain Concussion
Traumatic Brain Injury
Neurons
Equipment and Supplies
Parahippocampal Gyrus
Dentate Gyrus
Brain

Keywords

  • injury severity
  • neural stem cell proliferation
  • neurogenesis
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Traumatic Brain Injury Severity Affects Neurogenesis in Adult Mouse Hippocampus. / Wang, Xiaoting; Gao, Xiang; Michalski, Stephanie; Zhao, Shu; Chen, Jinhui.

In: Journal of Neurotrauma, Vol. 33, No. 8, 15.04.2016, p. 721-733.

Research output: Contribution to journalArticle

Wang, Xiaoting ; Gao, Xiang ; Michalski, Stephanie ; Zhao, Shu ; Chen, Jinhui. / Traumatic Brain Injury Severity Affects Neurogenesis in Adult Mouse Hippocampus. In: Journal of Neurotrauma. 2016 ; Vol. 33, No. 8. pp. 721-733.
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