Treating acute myeloid leukemia via HSC transplantation: A preliminary study of multi-objective personalization strategies

Ankush Chakrabarty, Serena M. Pearce, Robert P. Nelson, Ann E. Rundell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Older subjects with acute myeloid leukemia (AML) or those with co-morbid conditions may not withstand conventional conditioning chemotherapy/radiation prior to hematopoietic stem cell (HSC) transplantation. A relatively mild conditioning is therefore being investigated prior to HSC transplantation. This study investigates the potential to describe personalization of conditioning for each subject using nonlinear model predictive control. A nonlinear ordinary differential equation (ODE) mathematical model of the conditioning regimen and HSC engraftment dynamics is presented. Its simulated dynamics are compared with averaged values from a de-identified clinical white blood cell engraftment data. The controller determines the optimal conditioning strategy administered to patients prior to HSC transplantation. A multi-objective controller designs the conditioning regimen to minimize the number of cancerous cells while limiting collateral damage to the patients tissues. The study serves as a preliminary investigation into the capability of mathematical modeling to optimize conditioning prior to HSC transplantation for treatment of acute myeloid leukemia (AML) in humans.

Original languageEnglish (US)
Title of host publication2013 American Control Conference, ACC 2013
Pages3790-3795
Number of pages6
StatePublished - Sep 11 2013
Event2013 1st American Control Conference, ACC 2013 - Washington, DC, United States
Duration: Jun 17 2013Jun 19 2013

Publication series

NameProceedings of the American Control Conference
ISSN (Print)0743-1619

Other

Other2013 1st American Control Conference, ACC 2013
CountryUnited States
CityWashington, DC
Period6/17/136/19/13

Keywords

  • AML
  • hematopoeitic stem cell transplantation
  • multi-objective optimization
  • nonlinear MPC

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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    Chakrabarty, A., Pearce, S. M., Nelson, R. P., & Rundell, A. E. (2013). Treating acute myeloid leukemia via HSC transplantation: A preliminary study of multi-objective personalization strategies. In 2013 American Control Conference, ACC 2013 (pp. 3790-3795). [6580417] (Proceedings of the American Control Conference).