Treating hypertension in hemodialysis improves symptoms seemingly unrelated to volume excess

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BackgroundAmong hemodialysis patients, probing dry weight is an effective strategy for improving control of hypertension. Whether controlling hypertension improves or worsens symptoms among such patients remains unclear. The purpose of the study was to develop a tool to evaluate symptoms and examine the relationship of the change in these symptoms with blood pressure (BP) control. MethodsAmong patients participating in the Hemodialysis Patients Treated with Atenolol or Lisinopril (HDPAL) randomized controlled trial, a confirmatory factor analysis (CFA) was performed to establish the relationship between symptoms and organ systems. Next, the change in symptom scores pertaining to organ systems was analyzed using a mixed model. Finally, the independent effect of lowering home BP on change in symptoms was evaluated. ResultsAmong 133 participants where symptoms were available at baseline, CFA revealed four level 1 domains: gastrointestinal symptoms, dialysis-related symptoms, cardiovascular symptoms and general symptoms. All except dialysis-related symptoms were ascribed to uremia (level 2 domain). Uremic symptoms improved over 6 months and then increased. Dialysis-related symptoms (fatigue, cramps and orthostatic dizziness) did not worsen despite lowering home BP. Probing dry weight was independently associated with an improvement in cardiovascular symptoms such as shortness of breath. ConclusionsReducing BP through the use of a strategy that includes volume control and medication improves symptoms seemingly unrelated to volume excess. In long-term hemodialysis patients, treating hypertension using home BP measurements may improve well-being.

Original languageEnglish (US)
Pages (from-to)142-149
Number of pages8
JournalNephrology Dialysis Transplantation
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Renal Dialysis
Blood Pressure
Hypertension
Dialysis
Statistical Factor Analysis
Lisinopril
Weights and Measures
Muscle Cramp
Atenolol
Uremia
Dizziness
Dyspnea
Fatigue
Randomized Controlled Trials

Keywords

  • blood pressure
  • cardiovascular
  • hemodialysis
  • hypertension
  • symptoms

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Treating hypertension in hemodialysis improves symptoms seemingly unrelated to volume excess. / Agarwal, Rajiv.

In: Nephrology Dialysis Transplantation, Vol. 31, No. 1, 01.01.2016, p. 142-149.

Research output: Contribution to journalArticle

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