Treatment changes in prostatic hyperplasia and cancer, including androgen deprivation therapy and radiotherapy

D. G. Bostwick, D. Ramnani, L. Cheng

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Substantial and characteristic changes occur in the microscopic appearance and immunophenotype of the hyperplastic prostate and adenocarcinoma following androgen deprivation therapy and radiotherapy. These changes are rarely seen in untreated cancer, and in the authors' opinion, the combinations of features following therapy are sufficiently distinctive to warrant recognition. Pathologists must be aware of these distinct changes because of the reliance placed on nuclear and nucleolar size in the identification of prostate cancer, particularly in small specimens and lymph node metastases.

Original languageEnglish (US)
Pages (from-to)465-479
Number of pages15
JournalUrologic Clinics of North America
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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