Treatment of Carotid Restenosis Using Transcarotid Revascularization

S. Keisin Wang, Alexander H. King, Vikram S. Kashyap, Mazin I. Foteh, Ravi N. Ambani, Jeff M. Apple, Andres C. Fajardo, Raghu L. Motaganahalli

Research output: Contribution to journalArticle


Objective: Transcarotid artery revascularization (TCAR) using the ENROUTE Neuroprotection System (Silk Road Medical) is a United States Food and Drug Administration–approved treatment modality for stroke risk reduction in the setting of carotid artery stenosis. The goal of this investigation was to define the real-world outcomes associated with the application of this technique to patients presenting with restenosis after previous carotid endarterectomy (CEA) or transfemoral carotid artery stenting (TF-CAS). Methods: Retrospective review of prospectively maintained institutional databases capturing all nontrial TCARs performed between August 2013 and July 2018 using the ENROUTE Neuroprotection System was completed at 3 unaffiliated hospital systems and unified for descriptive outcomes analysis. Results: During the study period, 237 combined TCARs were performed at our respective institutions. Of these procedures, 55 stents were implanted for the indication of restenosis after previous carotid revascularization (47 CEA, 8 TF-CAS). Within the 30-day perioperative period, we observed no ipsilateral strokes or deaths; one patient experienced perioperative myocardial infarction (MI; 1.8%). We noted a 4.8% incidence of postoperative hematoma, but none of these events were clinically significant as no reinterventions were performed in any of the 55 patients. Additionally, we did not observe any cases of stent thrombosis or pulmonary embolus. Mean length of stay was 2.2 ± 2.8 days. Our mean follow-up duration was 15.0 ± 9.2 months. Throughout the follow-up period, we did not observe any additional stroke or MI events. Additionally, there were no cases of in-stent restenosis, thrombosis, or reinterventions. Conclusion: Transcarotid artery revascularization can be performed in patients with restenotic carotid arteries with acceptable rates of ipsilateral stroke, MI, and death as demonstrated in this small multi-institutional series.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalVascular and Endovascular Surgery
Issue number5
StatePublished - Jul 1 2020


  • carotid revascularization
  • restenosis
  • reverse flow
  • stenting
  • stroke
  • TCAR

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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    Wang, S. K., King, A. H., Kashyap, V. S., Foteh, M. I., Ambani, R. N., Apple, J. M., Fajardo, A. C., & Motaganahalli, R. L. (2020). Treatment of Carotid Restenosis Using Transcarotid Revascularization. Vascular and Endovascular Surgery, 54(5), 436-440.