Treatment of condyloma acuminatum with three different interferon-α preparations administered parenteraliy

A double-blind, placebo-controlled trial

Richard C. Reichman, David Oakes, William Bonnez, Darron Brown, H. Reid Mattison, Allyson Bailey-Farchione, Mark H. Stoler, Lisa M. Demeter, Steven K. Tyring, Lisa Miller, Richard Whitley, Holly Carveth, Melissa Weidner, Gerald Krueger, Anna Choi

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

One hundred seventy-eight patients were enrolled in a placebo-controlled trial to evaluate three interferon-a preparations administered parenterally for the treatment of condyloma acumina-tum. When all Interferon groups were combined and compared with placebo, Interferon recipients had greater rates of complete, 75%, 50%, and 25% lesion resolution than did placebo recipients (P = .21, P = .14, P = .02, and P = .02, respectively). Rates of lesion resolution were higher among women than among men, and women were more likely than men to respond to interferon. Virologic measurements in paired lesion biopsies did not correlate with interferon treatment or disease outcome. Although interferon toxicity was observed frequently, no participant withdrew from the study because of side effects, and dosage alterations were not required. Parenterally administered interferon-α is more effective than placebo in treating condyloma acuminatum, although rates of complete response are low. Different regimens, including combination therapy, should be evaluated for treatment of this common sexually transmitted disease.

Original languageEnglish
Pages (from-to)1270-1276
Number of pages7
JournalJournal of Infectious Diseases
Volume162
Issue number6
StatePublished - Dec 1990
Externally publishedYes

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Condylomata Acuminata
Interferons
Placebos
Therapeutics
Sexually Transmitted Diseases
Biopsy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Treatment of condyloma acuminatum with three different interferon-α preparations administered parenteraliy : A double-blind, placebo-controlled trial. / Reichman, Richard C.; Oakes, David; Bonnez, William; Brown, Darron; Mattison, H. Reid; Bailey-Farchione, Allyson; Stoler, Mark H.; Demeter, Lisa M.; Tyring, Steven K.; Miller, Lisa; Whitley, Richard; Carveth, Holly; Weidner, Melissa; Krueger, Gerald; Choi, Anna.

In: Journal of Infectious Diseases, Vol. 162, No. 6, 12.1990, p. 1270-1276.

Research output: Contribution to journalArticle

Reichman, RC, Oakes, D, Bonnez, W, Brown, D, Mattison, HR, Bailey-Farchione, A, Stoler, MH, Demeter, LM, Tyring, SK, Miller, L, Whitley, R, Carveth, H, Weidner, M, Krueger, G & Choi, A 1990, 'Treatment of condyloma acuminatum with three different interferon-α preparations administered parenteraliy: A double-blind, placebo-controlled trial', Journal of Infectious Diseases, vol. 162, no. 6, pp. 1270-1276.
Reichman, Richard C. ; Oakes, David ; Bonnez, William ; Brown, Darron ; Mattison, H. Reid ; Bailey-Farchione, Allyson ; Stoler, Mark H. ; Demeter, Lisa M. ; Tyring, Steven K. ; Miller, Lisa ; Whitley, Richard ; Carveth, Holly ; Weidner, Melissa ; Krueger, Gerald ; Choi, Anna. / Treatment of condyloma acuminatum with three different interferon-α preparations administered parenteraliy : A double-blind, placebo-controlled trial. In: Journal of Infectious Diseases. 1990 ; Vol. 162, No. 6. pp. 1270-1276.
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