Treatment of donor T cell-mediated hematopoietic suppression after haploidentical bone marrow transplantation by T cell modulation in a patient with severe combined immunodeficiency

D. Dilloo, H. Hanenberg, E. M. Schneider, M. Hauch, W. Nurnberger, B. M. Zimmer, R. Vohringer, P. Wernet, U. Gobel, S. E.G. Burdach

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Abstract

An 8-month-old male patient with severe combined immunodeficiency syndrome was transplanted with maternal, haploidentical T cell-depleted bone marrow without prior conditioning therapy. Acute graft-versus-host disease developed 2 weeks post bone marrow transplantation (BMT) and as successfully treated with cortisone. After cortisone withdrawal the patient developed myeloid and B cell depression concomitant with T cell activation. For specific T cell modulation, treatment with the T cell receptor (TCR) αβ chain-binding MoAb BMA031 as initiated in combination with cyclosporin A. GM-CSF as given to enhance myeloid reconstitution. About 1 year post BMT, B cell and granulocyte counts were within the normal range with stable chimerism in both lineages. B cell proliferation tests were normal and first signs of in vitro immunoglobulin synthesis occurred.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalBone Marrow Transplantation
Volume9
Issue number1
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Dilloo, D., Hanenberg, H., Schneider, E. M., Hauch, M., Nurnberger, W., Zimmer, B. M., Vohringer, R., Wernet, P., Gobel, U., & Burdach, S. E. G. (1992). Treatment of donor T cell-mediated hematopoietic suppression after haploidentical bone marrow transplantation by T cell modulation in a patient with severe combined immunodeficiency. Bone Marrow Transplantation, 9(1), 57-62.