Abstract
Our randomized double blinded comparison of acetaminophen versus analgesic and antiinflammatory doses of ibuprofen in the treatment of 182 subjects with knee osteoarthritis (OA) systematically evaluated soft tissue tenderness and joint swelling. Improvement in these signs of joint inflammation was associated with lessening of disability (p = 0.02), and reduction in rest pain (p = 0.07), but not with the drug treatment regimen. Thus, joint tenderness and swelling, presumptive evidence of synovitis, may not be a priori indications for use of an antiinflammatory drug, or predict greater responsiveness to treatment with an antiinflammatory drug than to a pure analgesic, in symptomatic treatment of patients with knee OA.
| Original language | English |
|---|---|
| Pages (from-to) | 1950-1954 |
| Number of pages | 5 |
| Journal | Journal of Rheumatology |
| Volume | 19 |
| Issue number | 12 |
| State | Published - 1992 |
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Keywords
- inflammation
- NSAID
- osteoarthritis
ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Treatment of knee osteoarthritis : Relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic. / Bradley, J. D.; Brandt, K. D.; Katz, Barry; Kalasinski, L. A.; Ryan, S. I.
In: Journal of Rheumatology, Vol. 19, No. 12, 1992, p. 1950-1954.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of knee osteoarthritis
T2 - Relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic
AU - Bradley, J. D.
AU - Brandt, K. D.
AU - Katz, Barry
AU - Kalasinski, L. A.
AU - Ryan, S. I.
PY - 1992
Y1 - 1992
N2 - Our randomized double blinded comparison of acetaminophen versus analgesic and antiinflammatory doses of ibuprofen in the treatment of 182 subjects with knee osteoarthritis (OA) systematically evaluated soft tissue tenderness and joint swelling. Improvement in these signs of joint inflammation was associated with lessening of disability (p = 0.02), and reduction in rest pain (p = 0.07), but not with the drug treatment regimen. Thus, joint tenderness and swelling, presumptive evidence of synovitis, may not be a priori indications for use of an antiinflammatory drug, or predict greater responsiveness to treatment with an antiinflammatory drug than to a pure analgesic, in symptomatic treatment of patients with knee OA.
AB - Our randomized double blinded comparison of acetaminophen versus analgesic and antiinflammatory doses of ibuprofen in the treatment of 182 subjects with knee osteoarthritis (OA) systematically evaluated soft tissue tenderness and joint swelling. Improvement in these signs of joint inflammation was associated with lessening of disability (p = 0.02), and reduction in rest pain (p = 0.07), but not with the drug treatment regimen. Thus, joint tenderness and swelling, presumptive evidence of synovitis, may not be a priori indications for use of an antiinflammatory drug, or predict greater responsiveness to treatment with an antiinflammatory drug than to a pure analgesic, in symptomatic treatment of patients with knee OA.
KW - inflammation
KW - NSAID
KW - osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=0027093390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027093390&partnerID=8YFLogxK
M3 - Article
C2 - 1294745
AN - SCOPUS:0027093390
VL - 19
SP - 1950
EP - 1954
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 12
ER -