Treatment of metastatic germ-cell tumors in men with adriamycin, vincristine, and bleomycin

M. A. Burgess, Lawrence Einhorn, J. A. Gottlieb

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

25 patients with metastatic germ-cell tumors were treated with a combination of adriamycin, vincristine, and bleomycin. 15 patients (60%) had previously received radiation therapy, chemotherapy, or both. 20 patients (80%) responded to treatment, with eight (32%) patients achieving a complete remission (CR) and 12 (48%) patients achieving a partial remission (PR). The median duration of response for the patients with PR was 4 mth, whereas 4 patients with a CR remain alive without evidence of disease for >3 yr after the initiation of treatment. Responses were observed in all tumor categories and apparently were not influenced by prior therapy. Side effects included gastrointestinal toxicity, alopecia, neuropathy, skin changes, mucositis, and myelosuppression (more severe in previously treated patients). Though moderate success was demonstrated for this chemotherapy regimen, it does not appear as effective as more recent regimens including vinblastine and bleomycin.

Original languageEnglish (US)
Pages (from-to)1447-1451
Number of pages5
JournalCancer Treatment Reports
Volume61
Issue number8
StatePublished - 1977
Externally publishedYes

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Germ Cell and Embryonal Neoplasms
Bleomycin
Vincristine
Doxorubicin
Therapeutics
Drug Therapy
Mucositis
Vinblastine
Alopecia
Radiotherapy
Skin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Treatment of metastatic germ-cell tumors in men with adriamycin, vincristine, and bleomycin. / Burgess, M. A.; Einhorn, Lawrence; Gottlieb, J. A.

In: Cancer Treatment Reports, Vol. 61, No. 8, 1977, p. 1447-1451.

Research output: Contribution to journalArticle

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