25 patients with metastatic germ-cell tumors were treated with a combination of adriamycin, vincristine, and bleomycin. 15 patients (60%) had previously received radiation therapy, chemotherapy, or both. 20 patients (80%) responded to treatment, with eight (32%) patients achieving a complete remission (CR) and 12 (48%) patients achieving a partial remission (PR). The median duration of response for the patients with PR was 4 mth, whereas 4 patients with a CR remain alive without evidence of disease for >3 yr after the initiation of treatment. Responses were observed in all tumor categories and apparently were not influenced by prior therapy. Side effects included gastrointestinal toxicity, alopecia, neuropathy, skin changes, mucositis, and myelosuppression (more severe in previously treated patients). Though moderate success was demonstrated for this chemotherapy regimen, it does not appear as effective as more recent regimens including vinblastine and bleomycin.
|Original language||English (US)|
|Number of pages||5|
|Journal||Cancer Treatment Reports|
|State||Published - Dec 1 1977|
ASJC Scopus subject areas
- Cancer Research