Treatment of Pseudomonas infections in peritoneal dialysis patients

Tim Taber, T. F. Hegeman, S. M. York, R. A. Kinney, D. H. Webb

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Pseudomonas species infections in the peritoneal dialysis population consist primarily of peritonitis or exit site infections. These organisms have traditionally proven difficult to eradicate, and the standard antibiotic regimen has carried the potential for nephrotoxicity. At our institution, all peritoneal dialysis patients with Pseudomonas exit site infections or peritonitis were treated with an antibiotic combination of intraperitoneal ceftazidime and oral ciprofloxacin. Treatment duration was dependent upon the site of infection. Recurrent exit site infections were treated with a repeated course of the antibiotics, and with surgical debridement and subsequent shaving of the external cuff of double-cuffed catheters. We saw a total of 11 Pseudomonas aeruginosa exit site infections in 7 patients (4 recurrent). Patients with recurrent infections were subsequently cured with the regimen as outlined above. Of 7 patients with Pseudomonas species peritonitis (aeruginosa, fluorescens, stutszeri, and maltophilia), 5 were cured with the initial antibiotic regimen. The 2 failures were both infected with Pseudomonas maltophilia, which is consistent with observed organism sensitivity data. The combination of ceftazidime and ciprofloxacin with the option for surgical debridement of the external cuff (in exit site infections) appears effective in the treatment of Pseudomonas species infections in the peritoneal dialysis population. Sensitivity data should be used to adjust the antibiotic regimen when appropriate.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalPeritoneal Dialysis International
Volume11
Issue number3
StatePublished - 1991

Fingerprint

Pseudomonas Infections
Peritoneal Dialysis
Infection
Anti-Bacterial Agents
Peritonitis
Ceftazidime
Debridement
Ciprofloxacin
Pseudomonas
Therapeutics
Stenotrophomonas maltophilia
Pseudomonas aeruginosa
Population
Catheters

Keywords

  • ceftazidime
  • ciprofloxacin
  • exit site infection
  • peritonitis
  • Pseudomonas species

ASJC Scopus subject areas

  • Nephrology

Cite this

Taber, T., Hegeman, T. F., York, S. M., Kinney, R. A., & Webb, D. H. (1991). Treatment of Pseudomonas infections in peritoneal dialysis patients. Peritoneal Dialysis International, 11(3), 213-216.

Treatment of Pseudomonas infections in peritoneal dialysis patients. / Taber, Tim; Hegeman, T. F.; York, S. M.; Kinney, R. A.; Webb, D. H.

In: Peritoneal Dialysis International, Vol. 11, No. 3, 1991, p. 213-216.

Research output: Contribution to journalArticle

Taber, T, Hegeman, TF, York, SM, Kinney, RA & Webb, DH 1991, 'Treatment of Pseudomonas infections in peritoneal dialysis patients', Peritoneal Dialysis International, vol. 11, no. 3, pp. 213-216.
Taber, Tim ; Hegeman, T. F. ; York, S. M. ; Kinney, R. A. ; Webb, D. H. / Treatment of Pseudomonas infections in peritoneal dialysis patients. In: Peritoneal Dialysis International. 1991 ; Vol. 11, No. 3. pp. 213-216.
@article{7da7d0dfd9ce4c1b917a36ba845c8d06,
title = "Treatment of Pseudomonas infections in peritoneal dialysis patients",
abstract = "Pseudomonas species infections in the peritoneal dialysis population consist primarily of peritonitis or exit site infections. These organisms have traditionally proven difficult to eradicate, and the standard antibiotic regimen has carried the potential for nephrotoxicity. At our institution, all peritoneal dialysis patients with Pseudomonas exit site infections or peritonitis were treated with an antibiotic combination of intraperitoneal ceftazidime and oral ciprofloxacin. Treatment duration was dependent upon the site of infection. Recurrent exit site infections were treated with a repeated course of the antibiotics, and with surgical debridement and subsequent shaving of the external cuff of double-cuffed catheters. We saw a total of 11 Pseudomonas aeruginosa exit site infections in 7 patients (4 recurrent). Patients with recurrent infections were subsequently cured with the regimen as outlined above. Of 7 patients with Pseudomonas species peritonitis (aeruginosa, fluorescens, stutszeri, and maltophilia), 5 were cured with the initial antibiotic regimen. The 2 failures were both infected with Pseudomonas maltophilia, which is consistent with observed organism sensitivity data. The combination of ceftazidime and ciprofloxacin with the option for surgical debridement of the external cuff (in exit site infections) appears effective in the treatment of Pseudomonas species infections in the peritoneal dialysis population. Sensitivity data should be used to adjust the antibiotic regimen when appropriate.",
keywords = "ceftazidime, ciprofloxacin, exit site infection, peritonitis, Pseudomonas species",
author = "Tim Taber and Hegeman, {T. F.} and York, {S. M.} and Kinney, {R. A.} and Webb, {D. H.}",
year = "1991",
language = "English",
volume = "11",
pages = "213--216",
journal = "Peritoneal Dialysis International",
issn = "0896-8608",
publisher = "Multimed Inc.",
number = "3",

}

TY - JOUR

T1 - Treatment of Pseudomonas infections in peritoneal dialysis patients

AU - Taber, Tim

AU - Hegeman, T. F.

AU - York, S. M.

AU - Kinney, R. A.

AU - Webb, D. H.

PY - 1991

Y1 - 1991

N2 - Pseudomonas species infections in the peritoneal dialysis population consist primarily of peritonitis or exit site infections. These organisms have traditionally proven difficult to eradicate, and the standard antibiotic regimen has carried the potential for nephrotoxicity. At our institution, all peritoneal dialysis patients with Pseudomonas exit site infections or peritonitis were treated with an antibiotic combination of intraperitoneal ceftazidime and oral ciprofloxacin. Treatment duration was dependent upon the site of infection. Recurrent exit site infections were treated with a repeated course of the antibiotics, and with surgical debridement and subsequent shaving of the external cuff of double-cuffed catheters. We saw a total of 11 Pseudomonas aeruginosa exit site infections in 7 patients (4 recurrent). Patients with recurrent infections were subsequently cured with the regimen as outlined above. Of 7 patients with Pseudomonas species peritonitis (aeruginosa, fluorescens, stutszeri, and maltophilia), 5 were cured with the initial antibiotic regimen. The 2 failures were both infected with Pseudomonas maltophilia, which is consistent with observed organism sensitivity data. The combination of ceftazidime and ciprofloxacin with the option for surgical debridement of the external cuff (in exit site infections) appears effective in the treatment of Pseudomonas species infections in the peritoneal dialysis population. Sensitivity data should be used to adjust the antibiotic regimen when appropriate.

AB - Pseudomonas species infections in the peritoneal dialysis population consist primarily of peritonitis or exit site infections. These organisms have traditionally proven difficult to eradicate, and the standard antibiotic regimen has carried the potential for nephrotoxicity. At our institution, all peritoneal dialysis patients with Pseudomonas exit site infections or peritonitis were treated with an antibiotic combination of intraperitoneal ceftazidime and oral ciprofloxacin. Treatment duration was dependent upon the site of infection. Recurrent exit site infections were treated with a repeated course of the antibiotics, and with surgical debridement and subsequent shaving of the external cuff of double-cuffed catheters. We saw a total of 11 Pseudomonas aeruginosa exit site infections in 7 patients (4 recurrent). Patients with recurrent infections were subsequently cured with the regimen as outlined above. Of 7 patients with Pseudomonas species peritonitis (aeruginosa, fluorescens, stutszeri, and maltophilia), 5 were cured with the initial antibiotic regimen. The 2 failures were both infected with Pseudomonas maltophilia, which is consistent with observed organism sensitivity data. The combination of ceftazidime and ciprofloxacin with the option for surgical debridement of the external cuff (in exit site infections) appears effective in the treatment of Pseudomonas species infections in the peritoneal dialysis population. Sensitivity data should be used to adjust the antibiotic regimen when appropriate.

KW - ceftazidime

KW - ciprofloxacin

KW - exit site infection

KW - peritonitis

KW - Pseudomonas species

UR - http://www.scopus.com/inward/record.url?scp=0025816078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025816078&partnerID=8YFLogxK

M3 - Article

C2 - 1912015

AN - SCOPUS:0025816078

VL - 11

SP - 213

EP - 216

JO - Peritoneal Dialysis International

JF - Peritoneal Dialysis International

SN - 0896-8608

IS - 3

ER -