Treatment of Pseudomonas infections in peritoneal dialysis patients

T. E. Taber, T. F. Hegeman, S. M. York, R. A. Kinney, D. H. Webb

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Pseudomonas species infections in the peritoneal dialysis population consist primarily of peritonitis or exit site infections. These organisms have traditionally proven difficult to eradicate, and the standard antibiotic regimen has carried the potential for nephrotoxicity. At our institution, all peritoneal dialysis patients with Pseudomonas exit site infections or peritonitis were treated with an antibiotic combination of intraperitoneal ceftazidime and oral ciprofloxacin. Treatment duration was dependent upon the site of infection. Recurrent exit site infections were treated with a repeated course of the antibiotics, and with surgical debridement and subsequent shaving of the external cuff of double-cuffed catheters. We saw a total of 11 Pseudomonas aeruginosa exit site infections in 7 patients (4 recurrent). Patients with recurrent infections were subsequently cured with the regimen as outlined above. Of 7 patients with Pseudomonas species peritonitis (aeruginosa, fluorescens, stutszeri, and maltophilia), 5 were cured with the initial antibiotic regimen. The 2 failures were both infected with Pseudomonas maltophilia, which is consistent with observed organism sensitivity data. The combination of ceftazidime and ciprofloxacin with the option for surgical debridement of the external cuff (in exit site infections) appears effective in the treatment of Pseudomonas species infections in the peritoneal dialysis population. Sensitivity data should be used to adjust the antibiotic regimen when appropriate.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalPeritoneal Dialysis International
Volume11
Issue number3
StatePublished - Jan 1 1991

Keywords

  • ceftazidime
  • ciprofloxacin
  • exit site infection
  • peritonitis
  • Pseudomonas species

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Treatment of Pseudomonas infections in peritoneal dialysis patients'. Together they form a unique fingerprint.

  • Cite this

    Taber, T. E., Hegeman, T. F., York, S. M., Kinney, R. A., & Webb, D. H. (1991). Treatment of Pseudomonas infections in peritoneal dialysis patients. Peritoneal Dialysis International, 11(3), 213-216.