Treatment of recurrent ventricular tachycardia and fibrillation with aprindine

Alfred F. Fasola, R. Joe Noble, Douglas P. Zipes

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Twenty-three patients with recurrent ventricular tachycardia or ventricular fibrillation, or both, were treated with aprindine, a new antiarrhythmic agent. It was found that: (1) no patient had a recurrence of ventricular fibrillation after aprindine therapy was begun, except as a terminal event subsequent to the development of acute myocardial infarction and cardiogenic shock or refractory congestive heart failure; (2) 6 patients experienced ventricular tachycardia after the loading dose, but with continued aprindine therapy the ventricular tachycardia was suppressed in 3 of these 6 patients, and a fourth patient was asymptomatic during brief paroxysms of ventricular tachycardia; (3) in 2 patients, aprindine was ineffective and was discontinued; (4) electrical cardioversion was not required in any patient receiving aprindine; (5) premature ventricular extrasystoles were decreased in 18 of the 23 patients treated with apprindine; (6) aprindine was discontinued in 1 patient because of intolerable side effects, although ventricular arrhythmias were suppressed in this patient; and (7) 5 patients died from acute myocardial infarction or severe heart failure while receiving aprindine.

Original languageEnglish
Pages (from-to)903-909
Number of pages7
JournalThe American Journal of Cardiology
Volume39
Issue number6
DOIs
StatePublished - 1977

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Aprindine
Ventricular Fibrillation
Ventricular Tachycardia
Therapeutics
Heart Failure
Myocardial Infarction
Electric Countershock
Ventricular Premature Complexes
Cardiogenic Shock

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Treatment of recurrent ventricular tachycardia and fibrillation with aprindine. / Fasola, Alfred F.; Joe Noble, R.; Zipes, Douglas P.

In: The American Journal of Cardiology, Vol. 39, No. 6, 1977, p. 903-909.

Research output: Contribution to journalArticle

Fasola, Alfred F. ; Joe Noble, R. ; Zipes, Douglas P. / Treatment of recurrent ventricular tachycardia and fibrillation with aprindine. In: The American Journal of Cardiology. 1977 ; Vol. 39, No. 6. pp. 903-909.
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