TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1

Y. Liu, R. Raheja, N. Yeh, D. Ciznadija, A. M. Pedraza, T. Ozawa, E. Hukkelhoven, H. Erdjument-Bromage, P. Tempst, N. P. Gauthier, C. Brennan, E. C. Holland, A. Koff

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor-induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21 WAF1/CIP1. Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.

Original languageEnglish (US)
Pages (from-to)308-315
Number of pages8
JournalOncogene
Volume33
Issue number3
DOIs
StatePublished - Jan 16 2014
Externally publishedYes

Keywords

  • PDGF
  • TRIM3
  • glioma
  • p21
  • stem/progenitor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Liu, Y., Raheja, R., Yeh, N., Ciznadija, D., Pedraza, A. M., Ozawa, T., Hukkelhoven, E., Erdjument-Bromage, H., Tempst, P., Gauthier, N. P., Brennan, C., Holland, E. C., & Koff, A. (2014). TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1. Oncogene, 33(3), 308-315. https://doi.org/10.1038/onc.2012.596