TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1

Yan Liu, R. Raheja, N. Yeh, D. Ciznadija, A. M. Pedraza, T. Ozawa, E. Hukkelhoven, H. Erdjument-Bromage, P. Tempst, N. P. Gauthier, C. Brennan, E. C. Holland, A. Koff

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor-induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21 WAF1/CIP1. Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.

Original languageEnglish (US)
Pages (from-to)308-315
Number of pages8
JournalOncogene
Volume33
Issue number3
DOIs
StatePublished - Jan 16 2014
Externally publishedYes

Fingerprint

Neoplasms
Loss of Heterozygosity
Chromosome Mapping
Cyclin D1
Platelet-Derived Growth Factor
Glioblastoma
Glioma
Genes
Antiviral Agents
Cell Differentiation
Incidence
Growth

Keywords

  • glioma
  • p21
  • PDGF
  • stem/progenitor
  • TRIM3

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Liu, Y., Raheja, R., Yeh, N., Ciznadija, D., Pedraza, A. M., Ozawa, T., ... Koff, A. (2014). TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1. Oncogene, 33(3), 308-315. https://doi.org/10.1038/onc.2012.596

TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1. / Liu, Yan; Raheja, R.; Yeh, N.; Ciznadija, D.; Pedraza, A. M.; Ozawa, T.; Hukkelhoven, E.; Erdjument-Bromage, H.; Tempst, P.; Gauthier, N. P.; Brennan, C.; Holland, E. C.; Koff, A.

In: Oncogene, Vol. 33, No. 3, 16.01.2014, p. 308-315.

Research output: Contribution to journalArticle

Liu, Y, Raheja, R, Yeh, N, Ciznadija, D, Pedraza, AM, Ozawa, T, Hukkelhoven, E, Erdjument-Bromage, H, Tempst, P, Gauthier, NP, Brennan, C, Holland, EC & Koff, A 2014, 'TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1', Oncogene, vol. 33, no. 3, pp. 308-315. https://doi.org/10.1038/onc.2012.596
Liu Y, Raheja R, Yeh N, Ciznadija D, Pedraza AM, Ozawa T et al. TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1. Oncogene. 2014 Jan 16;33(3):308-315. https://doi.org/10.1038/onc.2012.596
Liu, Yan ; Raheja, R. ; Yeh, N. ; Ciznadija, D. ; Pedraza, A. M. ; Ozawa, T. ; Hukkelhoven, E. ; Erdjument-Bromage, H. ; Tempst, P. ; Gauthier, N. P. ; Brennan, C. ; Holland, E. C. ; Koff, A. / TRIM3, a tumor suppressor linked to regulation of p21 Waf1/Cip1. In: Oncogene. 2014 ; Vol. 33, No. 3. pp. 308-315.
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