Trophic effects of interleukin-11 in rats with experimental short bowel syndrome

Q. Liu, X. X. Du, D. T. Schindel, Z. X. Yang, Frederick Rescorla, D. A. Williams, J. L. Grosfeld, S. Smith, W. H. Hendren, P. C. Guzzetta, S. W. Bruch

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Interleukin-11 (IL-11) is s multifunctional cytokine, derived from bone marrow stromal cells, that stimulates proliferation of stem/progenitor precursor cells in the small intestinal crypts and accelerates recovery of intestinal mucosa after cytoablative therapy. This study evaluates whether IL-11 can improve the function and structure of the small intestine and enhance adaptation in an experimental model of short bowel syndrome. After 90% small bowel resection, 32 Sprague-Dawley rats were divided randomly into eight experimental groups of four animals each. Four groups were treated with IL-11 (125 μg/kg twice daily, subcutaneously), and the four control groups were treated with a similar volume (0.1%) of bovine serum albumin (BSA). The animals were weighed daily and were killed on day 2, 4, 6, or 8; remnant small bowel was evaluated for villus height and crypt cell mitosis. The body weight of the animals that received IL-11 was significantly greater at the beginning of postoperative day 4 in comparison to that of the BSA groups (P < .01 during days 5 to 7). The rats that had IL-11 also had significantly greater villus height and crypt cell mitotic rates (P < .05). These observations suggest that IL-11 has a trophic effect on the small bowel during the adaptive phase that follows massive bowel resection and may be useful in the treatment of short bowel syndrome.

Original languageEnglish
Pages (from-to)1047-1051
Number of pages5
JournalJournal of Pediatric Surgery
Volume31
Issue number8
StatePublished - 1996

Fingerprint

Interleukin-11
Short Bowel Syndrome
Bovine Serum Albumin
Intestinal Mucosa
Mesenchymal Stromal Cells
Mitosis
Small Intestine
Sprague Dawley Rats
Theoretical Models
Stem Cells
Body Weight
Cell Proliferation
Cytokines
Control Groups

Keywords

  • cytokines
  • interleukin-11
  • intestinal adaptation
  • Short bowel syndrome
  • villus hyperplasia

ASJC Scopus subject areas

  • Surgery

Cite this

Liu, Q., Du, X. X., Schindel, D. T., Yang, Z. X., Rescorla, F., Williams, D. A., ... Bruch, S. W. (1996). Trophic effects of interleukin-11 in rats with experimental short bowel syndrome. Journal of Pediatric Surgery, 31(8), 1047-1051.

Trophic effects of interleukin-11 in rats with experimental short bowel syndrome. / Liu, Q.; Du, X. X.; Schindel, D. T.; Yang, Z. X.; Rescorla, Frederick; Williams, D. A.; Grosfeld, J. L.; Smith, S.; Hendren, W. H.; Guzzetta, P. C.; Bruch, S. W.

In: Journal of Pediatric Surgery, Vol. 31, No. 8, 1996, p. 1047-1051.

Research output: Contribution to journalArticle

Liu, Q, Du, XX, Schindel, DT, Yang, ZX, Rescorla, F, Williams, DA, Grosfeld, JL, Smith, S, Hendren, WH, Guzzetta, PC & Bruch, SW 1996, 'Trophic effects of interleukin-11 in rats with experimental short bowel syndrome', Journal of Pediatric Surgery, vol. 31, no. 8, pp. 1047-1051.
Liu Q, Du XX, Schindel DT, Yang ZX, Rescorla F, Williams DA et al. Trophic effects of interleukin-11 in rats with experimental short bowel syndrome. Journal of Pediatric Surgery. 1996;31(8):1047-1051.
Liu, Q. ; Du, X. X. ; Schindel, D. T. ; Yang, Z. X. ; Rescorla, Frederick ; Williams, D. A. ; Grosfeld, J. L. ; Smith, S. ; Hendren, W. H. ; Guzzetta, P. C. ; Bruch, S. W. / Trophic effects of interleukin-11 in rats with experimental short bowel syndrome. In: Journal of Pediatric Surgery. 1996 ; Vol. 31, No. 8. pp. 1047-1051.
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