Trout vascular and renal responses to atrial natriuretic factor and heart extracts

D. W. Duff, K. R. Olson

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Dorsal aortic pressure (DAP), urine flow rate, and urinary K+, Na+, and Cl- were monitored in chronically catheterized unanesthetized rainbow trout before and after injection of saline, tissue extracts, or synthetic (rat, Ile-26) atrial natriuretic factor (ANF). Synthetic ANF (1.0 and 10.0 μg/kg body wt) and extracts from trout atria and ventricles increased DAP, urine flow rate, and electrolyte excretion. Saline, skeletal muscle extracts, and 0.1 μg/kg body wt synthetic ANF had no effect on DAP and only minor effects on renal water and ion excretion. The slow-onset long-duration pressor response to ANF and heart extracts contrasted with a rapid short-acting pressor effect of epinephrine. Synthetic ANF (10 μg/kg body wt) and ventricular extracts produced marked increases in Na+ and Cl- excretion but only a mild diuresis. Much of the increase in urine flow rate appears to be due to solvent injection. These results show that trout hearts contain an ANF-like material and that mammalian and piscine ANF produce hemodynamic and renal effects upon intra-arterial injection.

Original languageEnglish (US)
Pages (from-to)R639-R642
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume251
Issue number3 (20/3)
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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