Tryptophan hydroxylase polymorphism is associated with age of onset of alcoholism related behaviors

In Won Chung, Heon Kim, William Sribney, Joo Bong Hong, Chul Ho Lee, Kyu Young Lee, Hong Mei Nan, Yong Sik Kim, Paul Manowitz

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The purpose of this study was to explore the association of a tryptophan hydroxylase gene polymorphism (TPH1 A218C) with the age of alcoholism onset in a Korean population. The genotype and allele frequencies of TPH1 were investigated in 182 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for alcohol dependence. Alcoholics with the TPH1 AA or AC genotypes had an earlier age of disease onset (median age of onset, 26.5 years) than those with the CC genotype (median age of onset, 30 years; p = .002). Age of onset has been used in classifying alcoholics. The TPH1 polymorphism may explain, in part, the biological basis for these typologies.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalAlcohol
Volume36
Issue number1
DOIs
StatePublished - May 1 2005
Externally publishedYes

Keywords

  • Alcoholism
  • Pharmacogenetics
  • Polymorphism (genetics)
  • Tryptophan hydroxylase

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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