TSLP

An epithelial cell cytokine that regulates t cell differentiation by conditioning dendritic cell maturation

Yong Jun Liu, Vasilli Soumelis, Norihiko Watanabe, Tomoki Ito, Yui Hsi Wang, Rene De Waal Malefyt, Miyuki Omori, Baohua Zhou, Steven F. Ziegler

Research output: Contribution to journalArticle

455 Citations (Scopus)

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen to T lymphocytes, and induce different forms of immunity and tolerance. The functional versatility of DCs depends on their remarkable ability to translate collectively the information from both the invading microbes and their resident tissue microenvironments and then make an appropriate immune response. Recent progress in understanding TLR biology has illuminated the mechanisms by which DCs link innate and adaptive antimicrobial immune responses. However, how tissue microenvironments shape the function of DCs has remained elusive. Recent studies of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that strongly activates DCs, provide evidence at a molecular level that epithelial cells/tissue microenvironments directly communicate with DCs. We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses.

Original languageEnglish (US)
Pages (from-to)193-219
Number of pages27
JournalAnnual Review of Immunology
Volume25
DOIs
StatePublished - 2007
Externally publishedYes

Fingerprint

Dendritic Cells
Cell Differentiation
Epithelial Cells
Cytokines
Central Tolerance
T-Lymphocytes
Cellular Microenvironment
Adaptive Immunity
Lymphoid Tissue
Antigen-Presenting Cells
thymic stromal lymphopoietin
Thymus Gland
Immunity
Homeostasis
Epithelium
Antigens
Infection

Keywords

  • Allergy
  • Inflammatory Th2
  • Memory T cell
  • Regulatory T cells
  • Thymus

ASJC Scopus subject areas

  • Immunology

Cite this

TSLP : An epithelial cell cytokine that regulates t cell differentiation by conditioning dendritic cell maturation. / Liu, Yong Jun; Soumelis, Vasilli; Watanabe, Norihiko; Ito, Tomoki; Wang, Yui Hsi; Malefyt, Rene De Waal; Omori, Miyuki; Zhou, Baohua; Ziegler, Steven F.

In: Annual Review of Immunology, Vol. 25, 2007, p. 193-219.

Research output: Contribution to journalArticle

Liu, Yong Jun ; Soumelis, Vasilli ; Watanabe, Norihiko ; Ito, Tomoki ; Wang, Yui Hsi ; Malefyt, Rene De Waal ; Omori, Miyuki ; Zhou, Baohua ; Ziegler, Steven F. / TSLP : An epithelial cell cytokine that regulates t cell differentiation by conditioning dendritic cell maturation. In: Annual Review of Immunology. 2007 ; Vol. 25. pp. 193-219.
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