T1 mapping for diagnosis of mild chronic pancreatitis

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Abstract

Purpose: To determine if the T1 relaxation time of the pancreas can detect parenchymal changes in mild chronic pancreatitis (CP). Materials and Methods: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study analyzed 98 patients with suspected mild CP. Patients were grouped as normal (n=53) or mild CP (n=45) based on history, presenting symptomatology, and concordant findings on both the secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and endoscopic retrograde cholangiopancreatography (ERCP). T1 maps were obtained in all patients using the same 3D gradient echo technique on the same 3T scanner. T1 relaxation times, fat signal fraction (FSF), and anterior-posterior (AP) diameter were correlated with the clinical diagnosis of CP. Results: There was a significant difference (P < 0.0001) in the T1 relaxation times between the control (mean=797 msec, 95% confidence interval [CI]: 730, 865) and mild CP group (mean=1099 msec, 95% CI: 1032, 1166). A T1 relaxation time threshold value of 900 msec was 80% sensitive (95% CI: 65, 90) and 69% specific (95% CI: 56, 82) for the diagnosis of mild CP (area under the curve [AUC]: 0.81). Multiple regression analysis showed that T1 relaxation time was the only statistically significant variable correlating with the diagnosis of CP (P < 0.0001). T1 relaxation times showed a weak positive correlation with the pancreatic FSF (ρ=0.33, P=0.01) in the control group, but not in the mild CP group. Conclusion: The T1 relaxation time of the pancreatic parenchyma was significantly increased in patients with mild CP. Therefore, T1 mapping might be used as a practical quantitative imaging technique for the evaluation of suspected mild CP.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
DOIs
StateAccepted/In press - 2016

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Chronic Pancreatitis
Confidence Intervals
Fats
Magnetic Resonance Cholangiopancreatography
Health Insurance Portability and Accountability Act
Secretin
Endoscopic Retrograde Cholangiopancreatography
Research Ethics Committees
Area Under Curve
Pancreas
Retrospective Studies
History
Regression Analysis
Control Groups

Keywords

  • Chronic pancreatitis
  • MRCP
  • MRI
  • T mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{31d36ffecdb44ec2ae79d0812d81367e,
title = "T1 mapping for diagnosis of mild chronic pancreatitis",
abstract = "Purpose: To determine if the T1 relaxation time of the pancreas can detect parenchymal changes in mild chronic pancreatitis (CP). Materials and Methods: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study analyzed 98 patients with suspected mild CP. Patients were grouped as normal (n=53) or mild CP (n=45) based on history, presenting symptomatology, and concordant findings on both the secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and endoscopic retrograde cholangiopancreatography (ERCP). T1 maps were obtained in all patients using the same 3D gradient echo technique on the same 3T scanner. T1 relaxation times, fat signal fraction (FSF), and anterior-posterior (AP) diameter were correlated with the clinical diagnosis of CP. Results: There was a significant difference (P < 0.0001) in the T1 relaxation times between the control (mean=797 msec, 95{\%} confidence interval [CI]: 730, 865) and mild CP group (mean=1099 msec, 95{\%} CI: 1032, 1166). A T1 relaxation time threshold value of 900 msec was 80{\%} sensitive (95{\%} CI: 65, 90) and 69{\%} specific (95{\%} CI: 56, 82) for the diagnosis of mild CP (area under the curve [AUC]: 0.81). Multiple regression analysis showed that T1 relaxation time was the only statistically significant variable correlating with the diagnosis of CP (P < 0.0001). T1 relaxation times showed a weak positive correlation with the pancreatic FSF (ρ=0.33, P=0.01) in the control group, but not in the mild CP group. Conclusion: The T1 relaxation time of the pancreatic parenchyma was significantly increased in patients with mild CP. Therefore, T1 mapping might be used as a practical quantitative imaging technique for the evaluation of suspected mild CP.",
keywords = "Chronic pancreatitis, MRCP, MRI, T mapping",
author = "Temel Tirkes and Chen Lin and Evan Fogel and Stuart Sherman and Qiushi Wang and Kumar Sandrasegaran",
year = "2016",
doi = "10.1002/jmri.25428",
language = "English (US)",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - T1 mapping for diagnosis of mild chronic pancreatitis

AU - Tirkes, Temel

AU - Lin, Chen

AU - Fogel, Evan

AU - Sherman, Stuart

AU - Wang, Qiushi

AU - Sandrasegaran, Kumar

PY - 2016

Y1 - 2016

N2 - Purpose: To determine if the T1 relaxation time of the pancreas can detect parenchymal changes in mild chronic pancreatitis (CP). Materials and Methods: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study analyzed 98 patients with suspected mild CP. Patients were grouped as normal (n=53) or mild CP (n=45) based on history, presenting symptomatology, and concordant findings on both the secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and endoscopic retrograde cholangiopancreatography (ERCP). T1 maps were obtained in all patients using the same 3D gradient echo technique on the same 3T scanner. T1 relaxation times, fat signal fraction (FSF), and anterior-posterior (AP) diameter were correlated with the clinical diagnosis of CP. Results: There was a significant difference (P < 0.0001) in the T1 relaxation times between the control (mean=797 msec, 95% confidence interval [CI]: 730, 865) and mild CP group (mean=1099 msec, 95% CI: 1032, 1166). A T1 relaxation time threshold value of 900 msec was 80% sensitive (95% CI: 65, 90) and 69% specific (95% CI: 56, 82) for the diagnosis of mild CP (area under the curve [AUC]: 0.81). Multiple regression analysis showed that T1 relaxation time was the only statistically significant variable correlating with the diagnosis of CP (P < 0.0001). T1 relaxation times showed a weak positive correlation with the pancreatic FSF (ρ=0.33, P=0.01) in the control group, but not in the mild CP group. Conclusion: The T1 relaxation time of the pancreatic parenchyma was significantly increased in patients with mild CP. Therefore, T1 mapping might be used as a practical quantitative imaging technique for the evaluation of suspected mild CP.

AB - Purpose: To determine if the T1 relaxation time of the pancreas can detect parenchymal changes in mild chronic pancreatitis (CP). Materials and Methods: This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study analyzed 98 patients with suspected mild CP. Patients were grouped as normal (n=53) or mild CP (n=45) based on history, presenting symptomatology, and concordant findings on both the secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and endoscopic retrograde cholangiopancreatography (ERCP). T1 maps were obtained in all patients using the same 3D gradient echo technique on the same 3T scanner. T1 relaxation times, fat signal fraction (FSF), and anterior-posterior (AP) diameter were correlated with the clinical diagnosis of CP. Results: There was a significant difference (P < 0.0001) in the T1 relaxation times between the control (mean=797 msec, 95% confidence interval [CI]: 730, 865) and mild CP group (mean=1099 msec, 95% CI: 1032, 1166). A T1 relaxation time threshold value of 900 msec was 80% sensitive (95% CI: 65, 90) and 69% specific (95% CI: 56, 82) for the diagnosis of mild CP (area under the curve [AUC]: 0.81). Multiple regression analysis showed that T1 relaxation time was the only statistically significant variable correlating with the diagnosis of CP (P < 0.0001). T1 relaxation times showed a weak positive correlation with the pancreatic FSF (ρ=0.33, P=0.01) in the control group, but not in the mild CP group. Conclusion: The T1 relaxation time of the pancreatic parenchyma was significantly increased in patients with mild CP. Therefore, T1 mapping might be used as a practical quantitative imaging technique for the evaluation of suspected mild CP.

KW - Chronic pancreatitis

KW - MRCP

KW - MRI

KW - T mapping

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