Tuberculosis in Antiretroviral Treatment Programs in Lower Income Countries

Availability and Use of Diagnostics and Screening

Lukas Fenner, Marie Ballif, Claire Graber, Venerandah Nhandu, Jean Claude Dusingize, Claudia P. Cortes, Gabriela Carriquiry, Kathryn Anastos, Daniela Garone, Eefje Jong, Joachim Charles Gnokoro, Omar Sued, Samuel Ajayi, Lameck Diero, Kara Wools-Kaloustian, Sasisopin Kiertiburanakul, Barbara Castelnuovo, Charlotte Lewden, Nicolas Durier, Timothy R. Sterling & 1 others Matthias Egger

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives:In resource-constrained settings, tuberculosis (TB) is a common opportunistic infection and cause of death in HIV-infected persons. TB may be present at the start of antiretroviral therapy (ART), but it is often under-diagnosed. We describe approaches to TB diagnosis and screening of TB in ART programs in low- and middle-income countries.Methods and findings:We surveyed ART programs treating HIV-infected adults in sub-Saharan Africa, Asia and Latin America in 2012 using online questionnaires to collect program-level and patient-level data. Forty-seven sites from 26 countries participated. Patient-level data were collected on 987 adult TB patients from 40 sites (median age 34.7 years; 54% female). Sputum smear microscopy and chest radiograph were available in 47 (100%) sites, TB culture in 44 (94%), and Xpert MTB/RIF in 23 (49%). Xpert MTB/RIF was rarely available in Central Africa and South America. In sites with access to these diagnostics, microscopy was used in 745 (76%) patients diagnosed with TB, culture in 220 (24%), and chest X-ray in 688 (70%) patients. When free of charge culture was done in 27% of patients, compared to 21% when there was a fee (p = 0.033). Corresponding percentages for Xpert MTB/RIF were 26% and 15% of patients (p = 0.001). Screening practices for active disease before starting ART included symptom screening (46 sites, 98%), chest X-ray (38, 81%), sputum microscopy (37, 79%), culture (16, 34%), and Xpert MTB/RIF (5, 11%).Conclusions:Mycobacterial culture was infrequently used despite its availability at most sites, while Xpert MTB/RIF was not generally available. Use of available diagnostics was higher when offered free of charge.

Original languageEnglish
Article numbere77697
JournalPLoS One
Volume8
Issue number10
DOIs
StatePublished - Oct 17 2013

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tuberculosis
Microscopic examination
Screening
income
Tuberculosis
Availability
screening
chest
X rays
Microscopy
microscopy
therapeutics
Thorax
Sputum
Therapeutics
X-radiation
X-Rays
HIV
Central Africa
Central America

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Fenner, L., Ballif, M., Graber, C., Nhandu, V., Dusingize, J. C., Cortes, C. P., ... Egger, M. (2013). Tuberculosis in Antiretroviral Treatment Programs in Lower Income Countries: Availability and Use of Diagnostics and Screening. PLoS One, 8(10), [e77697]. https://doi.org/10.1371/journal.pone.0077697

Tuberculosis in Antiretroviral Treatment Programs in Lower Income Countries : Availability and Use of Diagnostics and Screening. / Fenner, Lukas; Ballif, Marie; Graber, Claire; Nhandu, Venerandah; Dusingize, Jean Claude; Cortes, Claudia P.; Carriquiry, Gabriela; Anastos, Kathryn; Garone, Daniela; Jong, Eefje; Gnokoro, Joachim Charles; Sued, Omar; Ajayi, Samuel; Diero, Lameck; Wools-Kaloustian, Kara; Kiertiburanakul, Sasisopin; Castelnuovo, Barbara; Lewden, Charlotte; Durier, Nicolas; Sterling, Timothy R.; Egger, Matthias.

In: PLoS One, Vol. 8, No. 10, e77697, 17.10.2013.

Research output: Contribution to journalArticle

Fenner, L, Ballif, M, Graber, C, Nhandu, V, Dusingize, JC, Cortes, CP, Carriquiry, G, Anastos, K, Garone, D, Jong, E, Gnokoro, JC, Sued, O, Ajayi, S, Diero, L, Wools-Kaloustian, K, Kiertiburanakul, S, Castelnuovo, B, Lewden, C, Durier, N, Sterling, TR & Egger, M 2013, 'Tuberculosis in Antiretroviral Treatment Programs in Lower Income Countries: Availability and Use of Diagnostics and Screening', PLoS One, vol. 8, no. 10, e77697. https://doi.org/10.1371/journal.pone.0077697
Fenner, Lukas ; Ballif, Marie ; Graber, Claire ; Nhandu, Venerandah ; Dusingize, Jean Claude ; Cortes, Claudia P. ; Carriquiry, Gabriela ; Anastos, Kathryn ; Garone, Daniela ; Jong, Eefje ; Gnokoro, Joachim Charles ; Sued, Omar ; Ajayi, Samuel ; Diero, Lameck ; Wools-Kaloustian, Kara ; Kiertiburanakul, Sasisopin ; Castelnuovo, Barbara ; Lewden, Charlotte ; Durier, Nicolas ; Sterling, Timothy R. ; Egger, Matthias. / Tuberculosis in Antiretroviral Treatment Programs in Lower Income Countries : Availability and Use of Diagnostics and Screening. In: PLoS One. 2013 ; Vol. 8, No. 10.
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abstract = "Objectives:In resource-constrained settings, tuberculosis (TB) is a common opportunistic infection and cause of death in HIV-infected persons. TB may be present at the start of antiretroviral therapy (ART), but it is often under-diagnosed. We describe approaches to TB diagnosis and screening of TB in ART programs in low- and middle-income countries.Methods and findings:We surveyed ART programs treating HIV-infected adults in sub-Saharan Africa, Asia and Latin America in 2012 using online questionnaires to collect program-level and patient-level data. Forty-seven sites from 26 countries participated. Patient-level data were collected on 987 adult TB patients from 40 sites (median age 34.7 years; 54{\%} female). Sputum smear microscopy and chest radiograph were available in 47 (100{\%}) sites, TB culture in 44 (94{\%}), and Xpert MTB/RIF in 23 (49{\%}). Xpert MTB/RIF was rarely available in Central Africa and South America. In sites with access to these diagnostics, microscopy was used in 745 (76{\%}) patients diagnosed with TB, culture in 220 (24{\%}), and chest X-ray in 688 (70{\%}) patients. When free of charge culture was done in 27{\%} of patients, compared to 21{\%} when there was a fee (p = 0.033). Corresponding percentages for Xpert MTB/RIF were 26{\%} and 15{\%} of patients (p = 0.001). Screening practices for active disease before starting ART included symptom screening (46 sites, 98{\%}), chest X-ray (38, 81{\%}), sputum microscopy (37, 79{\%}), culture (16, 34{\%}), and Xpert MTB/RIF (5, 11{\%}).Conclusions:Mycobacterial culture was infrequently used despite its availability at most sites, while Xpert MTB/RIF was not generally available. Use of available diagnostics was higher when offered free of charge.",
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T2 - Availability and Use of Diagnostics and Screening

AU - Fenner, Lukas

AU - Ballif, Marie

AU - Graber, Claire

AU - Nhandu, Venerandah

AU - Dusingize, Jean Claude

AU - Cortes, Claudia P.

AU - Carriquiry, Gabriela

AU - Anastos, Kathryn

AU - Garone, Daniela

AU - Jong, Eefje

AU - Gnokoro, Joachim Charles

AU - Sued, Omar

AU - Ajayi, Samuel

AU - Diero, Lameck

AU - Wools-Kaloustian, Kara

AU - Kiertiburanakul, Sasisopin

AU - Castelnuovo, Barbara

AU - Lewden, Charlotte

AU - Durier, Nicolas

AU - Sterling, Timothy R.

AU - Egger, Matthias

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N2 - Objectives:In resource-constrained settings, tuberculosis (TB) is a common opportunistic infection and cause of death in HIV-infected persons. TB may be present at the start of antiretroviral therapy (ART), but it is often under-diagnosed. We describe approaches to TB diagnosis and screening of TB in ART programs in low- and middle-income countries.Methods and findings:We surveyed ART programs treating HIV-infected adults in sub-Saharan Africa, Asia and Latin America in 2012 using online questionnaires to collect program-level and patient-level data. Forty-seven sites from 26 countries participated. Patient-level data were collected on 987 adult TB patients from 40 sites (median age 34.7 years; 54% female). Sputum smear microscopy and chest radiograph were available in 47 (100%) sites, TB culture in 44 (94%), and Xpert MTB/RIF in 23 (49%). Xpert MTB/RIF was rarely available in Central Africa and South America. In sites with access to these diagnostics, microscopy was used in 745 (76%) patients diagnosed with TB, culture in 220 (24%), and chest X-ray in 688 (70%) patients. When free of charge culture was done in 27% of patients, compared to 21% when there was a fee (p = 0.033). Corresponding percentages for Xpert MTB/RIF were 26% and 15% of patients (p = 0.001). Screening practices for active disease before starting ART included symptom screening (46 sites, 98%), chest X-ray (38, 81%), sputum microscopy (37, 79%), culture (16, 34%), and Xpert MTB/RIF (5, 11%).Conclusions:Mycobacterial culture was infrequently used despite its availability at most sites, while Xpert MTB/RIF was not generally available. Use of available diagnostics was higher when offered free of charge.

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