Tuberculous Meningitis

Karen Roos, Hans Walter Pfister

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter presents a discussion on tuberculous meningitis. Tuberculous meningitis presents as either a subacute or a chronic meningitis, characterized by fever, headache, night sweats, and malaise, or a fulminant meningoencephalitis with coma, raised intracranial pressure, seizure activity, and stroke. In children, tuberculous meningitis occurs during primary infection with Mycobacterium tuberculosis. In adults, tuberculous meningitis does not occur during the course of primary infection, but rather from endogenous reactivation of infection in caseous tuberculous foci adjacent to the subarachnoid space that developed during hematogenous spread of tubercle bacilli in the course of an earlier primary infection, usually pulmonary tuberculosis. Meningitis is the result of the discharge of bacilli and tuberculous antigens into the subarachnoid space. It is not known what causes the growth and rupture of caseous lesions, but immunological mechanisms most likely have a role. The differential diagnosis of tuberculous meningitis includes those diseases that cause this combination of symptoms with a cerebrospinal fluid (CSF) lymphocytic pleocytosis and a mildly decreased glucose concentration. A person becomes infected with M. tuberculosis when they inhale aerosolized droplet nuclei containing tubercle bacilli. Hydrocephalus is the most common abnormality on neuroimaging and often progresses during the course of the disease. The chapter discusses practical management and adjunctive therapy.

Original languageEnglish
Title of host publicationNeurological Disorders: Course and Treatment: Second Edition
PublisherElsevier Inc.
Pages559-565
Number of pages7
ISBN (Print)9780121258313
DOIs
StatePublished - 2003

Fingerprint

Meningeal Tuberculosis
Bacillus
Subarachnoid Space
Infection
Meningitis
Mycobacterium tuberculosis
Meningoencephalitis
Sweat
Leukocytosis
Intracranial Pressure
Hydrocephalus
Coma
Pulmonary Tuberculosis
Neuroimaging
Headache
Cerebrospinal Fluid
Rupture
Seizures
Differential Diagnosis
Fever

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Roos, K., & Pfister, H. W. (2003). Tuberculous Meningitis. In Neurological Disorders: Course and Treatment: Second Edition (pp. 559-565). Elsevier Inc.. https://doi.org/10.1016/B978-012125831-3/50239-2

Tuberculous Meningitis. / Roos, Karen; Pfister, Hans Walter.

Neurological Disorders: Course and Treatment: Second Edition. Elsevier Inc., 2003. p. 559-565.

Research output: Chapter in Book/Report/Conference proceedingChapter

Roos, K & Pfister, HW 2003, Tuberculous Meningitis. in Neurological Disorders: Course and Treatment: Second Edition. Elsevier Inc., pp. 559-565. https://doi.org/10.1016/B978-012125831-3/50239-2
Roos K, Pfister HW. Tuberculous Meningitis. In Neurological Disorders: Course and Treatment: Second Edition. Elsevier Inc. 2003. p. 559-565 https://doi.org/10.1016/B978-012125831-3/50239-2
Roos, Karen ; Pfister, Hans Walter. / Tuberculous Meningitis. Neurological Disorders: Course and Treatment: Second Edition. Elsevier Inc., 2003. pp. 559-565
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