Tubular mechanisms in proteinuria

Sudhanshu K. Verma, Bruce Molitoris

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Chronic progressive nephropathies, independent of the type of initial insult, are often associated with high levels of urinary protein excretion. In addition to well established glomerular role in proteinuria, recent studies have shown that proximal tubular cell plays important role in development of proteinuria both under physiologic and pathologic conditions. Many single-site mutations and complete PTC dysfunction result in a high level of albuminuria, without any histologic or electron microscopy structural alterations in the glomerular filtration barrier. Reabsorption of filtered albumin involves a low-capacity/high-affinity megalin-cubulin receptor-mediated process and a high-capacity/low-affinity, process that could be fluid-phase endocytosis. Future studies are warranted examining proteinuria not only as a glomerular impairment but also as proximal tubule dysfunction and may lead to many new advances in the diagnosis and treatment of proteinuric states.

Original languageEnglish (US)
Title of host publicationProteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance
PublisherSpringer International Publishing
Pages23-40
Number of pages18
ISBN (Electronic)9783319433592
ISBN (Print)9783319433578
DOIs
StatePublished - Jan 1 2016

Fingerprint

Low Density Lipoprotein Receptor-Related Protein-2
Factor IX
Proteinuria
Electron microscopy
affinity
Albumins
excretion
Fluids
impairment
Glomerular Filtration Barrier
mutations
albumins
electron microscopy
Proteins
Albuminuria
Endocytosis
microscopy
proteins
fluids
Electron Microscopy

Keywords

  • Albuminuria
  • Kidney
  • Proteinuria
  • Proximal tubule cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Physics and Astronomy(all)

Cite this

Verma, S. K., & Molitoris, B. (2016). Tubular mechanisms in proteinuria. In Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance (pp. 23-40). Springer International Publishing. https://doi.org/10.1007/978-3-319-43359-2_3

Tubular mechanisms in proteinuria. / Verma, Sudhanshu K.; Molitoris, Bruce.

Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer International Publishing, 2016. p. 23-40.

Research output: Chapter in Book/Report/Conference proceedingChapter

Verma, SK & Molitoris, B 2016, Tubular mechanisms in proteinuria. in Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer International Publishing, pp. 23-40. https://doi.org/10.1007/978-3-319-43359-2_3
Verma SK, Molitoris B. Tubular mechanisms in proteinuria. In Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer International Publishing. 2016. p. 23-40 https://doi.org/10.1007/978-3-319-43359-2_3
Verma, Sudhanshu K. ; Molitoris, Bruce. / Tubular mechanisms in proteinuria. Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer International Publishing, 2016. pp. 23-40
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