Tubular mechanisms in proteinuria

Sudhanshu K. Verma, Bruce A. Molitoris

Research output: Chapter in Book/Report/Conference proceedingChapter


Chronic progressive nephropathies, independent of the type of initial insult, are often associated with high levels of urinary protein excretion. In addition to well established glomerular role in proteinuria, recent studies have shown that proximal tubular cell plays important role in development of proteinuria both under physiologic and pathologic conditions. Many single-site mutations and complete PTC dysfunction result in a high level of albuminuria, without any histologic or electron microscopy structural alterations in the glomerular filtration barrier. Reabsorption of filtered albumin involves a low-capacity/high-affinity megalin-cubulin receptor-mediated process and a high-capacity/low-affinity, process that could be fluid-phase endocytosis. Future studies are warranted examining proteinuria not only as a glomerular impairment but also as proximal tubule dysfunction and may lead to many new advances in the diagnosis and treatment of proteinuric states.

Original languageEnglish (US)
Title of host publicationProteinuria
Subtitle of host publicationBasic Mechanisms, Pathophysiology and Clinical Relevance
PublisherSpringer International Publishing
Number of pages18
ISBN (Electronic)9783319433592
ISBN (Print)9783319433578
StatePublished - Jan 1 2016


  • Albuminuria
  • Kidney
  • Proteinuria
  • Proximal tubule cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Physics and Astronomy(all)

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    Verma, S. K., & Molitoris, B. A. (2016). Tubular mechanisms in proteinuria. In Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance (pp. 23-40). Springer International Publishing. https://doi.org/10.1007/978-3-319-43359-2_3