Tubular sites of potassium regulation in the normal and uninephrectomized rat

H. H. Bengele, A. Evan, E. R. McNamara, E. A. Alexander

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tubular handling of potassium was studied in the Charles River CD (cesarean derived) rat by clearance, micropuncture, and anatomic techniques. The following groups were evaluated: group I, hydropenia; group II, KCl-mannitol infusion; group III, 10% body wt saline loading; group IV, uninephrectomy, hydropenia; and group V, uninephrectomy, saline loading. Comparison of micropuncture samples from early and late distal collection sites (LDCS) and urine collections revealed no net K transport along the distal convoluted tubule in groups I and III-V but net addition of K in all groups beyond the LDCS. Absolute K secretion beyond the LDCS appeared to be flow dependent in groups I-III. The LDCS was noted by light and electron microscopy always to be lined with collecting tubule epithelium. We conclude that no net change in potassium transport occurs along the superficial distal convoluted tubule during hydropenia or saline loading in normal or uninephrectomized Charles River CD rats, but secretion is demonstrable during KCl infusion. Net addition of potassium beyond the LDCS was noted in all groups and this addition was enhanced by uninephrectomy.

Original languageEnglish (US)
Pages (from-to)F146-F153
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume3
Issue number2
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Physiology

Cite this

Tubular sites of potassium regulation in the normal and uninephrectomized rat. / Bengele, H. H.; Evan, A.; McNamara, E. R.; Alexander, E. A.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 3, No. 2, 01.01.1978, p. F146-F153.

Research output: Contribution to journalArticle

@article{892a1ba5f6c14241bea20be43bb55ce4,
title = "Tubular sites of potassium regulation in the normal and uninephrectomized rat",
abstract = "Tubular handling of potassium was studied in the Charles River CD (cesarean derived) rat by clearance, micropuncture, and anatomic techniques. The following groups were evaluated: group I, hydropenia; group II, KCl-mannitol infusion; group III, 10{\%} body wt saline loading; group IV, uninephrectomy, hydropenia; and group V, uninephrectomy, saline loading. Comparison of micropuncture samples from early and late distal collection sites (LDCS) and urine collections revealed no net K transport along the distal convoluted tubule in groups I and III-V but net addition of K in all groups beyond the LDCS. Absolute K secretion beyond the LDCS appeared to be flow dependent in groups I-III. The LDCS was noted by light and electron microscopy always to be lined with collecting tubule epithelium. We conclude that no net change in potassium transport occurs along the superficial distal convoluted tubule during hydropenia or saline loading in normal or uninephrectomized Charles River CD rats, but secretion is demonstrable during KCl infusion. Net addition of potassium beyond the LDCS was noted in all groups and this addition was enhanced by uninephrectomy.",
author = "Bengele, {H. H.} and A. Evan and McNamara, {E. R.} and Alexander, {E. A.}",
year = "1978",
month = "1",
day = "1",
language = "English (US)",
volume = "3",
pages = "F146--F153",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "0002-9513",
number = "2",

}

TY - JOUR

T1 - Tubular sites of potassium regulation in the normal and uninephrectomized rat

AU - Bengele, H. H.

AU - Evan, A.

AU - McNamara, E. R.

AU - Alexander, E. A.

PY - 1978/1/1

Y1 - 1978/1/1

N2 - Tubular handling of potassium was studied in the Charles River CD (cesarean derived) rat by clearance, micropuncture, and anatomic techniques. The following groups were evaluated: group I, hydropenia; group II, KCl-mannitol infusion; group III, 10% body wt saline loading; group IV, uninephrectomy, hydropenia; and group V, uninephrectomy, saline loading. Comparison of micropuncture samples from early and late distal collection sites (LDCS) and urine collections revealed no net K transport along the distal convoluted tubule in groups I and III-V but net addition of K in all groups beyond the LDCS. Absolute K secretion beyond the LDCS appeared to be flow dependent in groups I-III. The LDCS was noted by light and electron microscopy always to be lined with collecting tubule epithelium. We conclude that no net change in potassium transport occurs along the superficial distal convoluted tubule during hydropenia or saline loading in normal or uninephrectomized Charles River CD rats, but secretion is demonstrable during KCl infusion. Net addition of potassium beyond the LDCS was noted in all groups and this addition was enhanced by uninephrectomy.

AB - Tubular handling of potassium was studied in the Charles River CD (cesarean derived) rat by clearance, micropuncture, and anatomic techniques. The following groups were evaluated: group I, hydropenia; group II, KCl-mannitol infusion; group III, 10% body wt saline loading; group IV, uninephrectomy, hydropenia; and group V, uninephrectomy, saline loading. Comparison of micropuncture samples from early and late distal collection sites (LDCS) and urine collections revealed no net K transport along the distal convoluted tubule in groups I and III-V but net addition of K in all groups beyond the LDCS. Absolute K secretion beyond the LDCS appeared to be flow dependent in groups I-III. The LDCS was noted by light and electron microscopy always to be lined with collecting tubule epithelium. We conclude that no net change in potassium transport occurs along the superficial distal convoluted tubule during hydropenia or saline loading in normal or uninephrectomized Charles River CD rats, but secretion is demonstrable during KCl infusion. Net addition of potassium beyond the LDCS was noted in all groups and this addition was enhanced by uninephrectomy.

UR - http://www.scopus.com/inward/record.url?scp=0018247154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018247154&partnerID=8YFLogxK

M3 - Article

C2 - 623306

AN - SCOPUS:0018247154

VL - 3

SP - F146-F153

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 0002-9513

IS - 2

ER -