Tubulocystic carcinoma of the kidney with poorly differentiated foci

A series of 3 cases with fluorescence in situ hybridization analysis

Turki O. Al-Hussain, Liang Cheng, Shaobo Zhang, Jonathan I. Epstein

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

We identified 3 consult cases of tubulocystic renal cell carcinoma with poorly differentiated areas. Two lesions measuring 9.5 and 3.8 cm were described as partly solid and cystic. One case was grossly a 14.0-cm cyst with a granular lining. Microscopically, all had classic areas of circumscribed tubulocystic renal cell carcinoma occupying 30%, 80%, and 90% of the tumor; 2 cases had small components of papillary renal cell carcinoma, and 1 case had a central large cystic component. In 2 cases, proliferations of small tubules infiltrated away from the main mass with typical features of collecting duct carcinoma. In the third case, a focus of poorly differentiated carcinoma was seen adjacent to the tubulocystic renal cell carcinoma. In 2 cases, tumor invaded perirenal tissue. The third case was organ confined with vascular invasion. One patient died 9 months postoperatively with metastases to the abdominal wall and femur. The second case developed a recurrence in the renal bed 3 years postoperatively. The third patient was lost to follow-up. Fluorescence in situ hybridization studies results showed some features overlapping with papillary renal cell carcinoma in both the tubulocystic and collecting duct-like components and with 1 exception showed identical cytogenetic findings between the 2 components. Morphologically, in 2 cases, the collecting duct-like areas were also indistinguishable from collecting duct carcinoma suggesting a relationship between the 2 entities. This is the first series and only the second report of tubulocystic renal cell carcinoma with poorly differentiated components and documents the increased the risk of aggressive behavior above that of usual tubulocystic renal cell carcinoma.

Original languageEnglish
Pages (from-to)1406-1411
Number of pages6
JournalHuman Pathology
Volume44
Issue number7
DOIs
StatePublished - Jul 2013

Fingerprint

Fluorescence In Situ Hybridization
Renal Cell Carcinoma
Carcinoma
Kidney
Lost to Follow-Up
Abdominal Wall
Risk-Taking
Cytogenetics
Femur
Blood Vessels
Cysts
Neoplasms
Neoplasm Metastasis
Recurrence

Keywords

  • Collecting duct carcinoma
  • Papillary renal cell carcinoma
  • Renal cell carcinoma
  • Tubulocystic carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tubulocystic carcinoma of the kidney with poorly differentiated foci : A series of 3 cases with fluorescence in situ hybridization analysis. / Al-Hussain, Turki O.; Cheng, Liang; Zhang, Shaobo; Epstein, Jonathan I.

In: Human Pathology, Vol. 44, No. 7, 07.2013, p. 1406-1411.

Research output: Contribution to journalArticle

@article{c69ef7b8b25e47a29288064289f383e3,
title = "Tubulocystic carcinoma of the kidney with poorly differentiated foci: A series of 3 cases with fluorescence in situ hybridization analysis",
abstract = "We identified 3 consult cases of tubulocystic renal cell carcinoma with poorly differentiated areas. Two lesions measuring 9.5 and 3.8 cm were described as partly solid and cystic. One case was grossly a 14.0-cm cyst with a granular lining. Microscopically, all had classic areas of circumscribed tubulocystic renal cell carcinoma occupying 30{\%}, 80{\%}, and 90{\%} of the tumor; 2 cases had small components of papillary renal cell carcinoma, and 1 case had a central large cystic component. In 2 cases, proliferations of small tubules infiltrated away from the main mass with typical features of collecting duct carcinoma. In the third case, a focus of poorly differentiated carcinoma was seen adjacent to the tubulocystic renal cell carcinoma. In 2 cases, tumor invaded perirenal tissue. The third case was organ confined with vascular invasion. One patient died 9 months postoperatively with metastases to the abdominal wall and femur. The second case developed a recurrence in the renal bed 3 years postoperatively. The third patient was lost to follow-up. Fluorescence in situ hybridization studies results showed some features overlapping with papillary renal cell carcinoma in both the tubulocystic and collecting duct-like components and with 1 exception showed identical cytogenetic findings between the 2 components. Morphologically, in 2 cases, the collecting duct-like areas were also indistinguishable from collecting duct carcinoma suggesting a relationship between the 2 entities. This is the first series and only the second report of tubulocystic renal cell carcinoma with poorly differentiated components and documents the increased the risk of aggressive behavior above that of usual tubulocystic renal cell carcinoma.",
keywords = "Collecting duct carcinoma, Papillary renal cell carcinoma, Renal cell carcinoma, Tubulocystic carcinoma",
author = "Al-Hussain, {Turki O.} and Liang Cheng and Shaobo Zhang and Epstein, {Jonathan I.}",
year = "2013",
month = "7",
doi = "10.1016/j.humpath.2012.11.015",
language = "English",
volume = "44",
pages = "1406--1411",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "7",

}

TY - JOUR

T1 - Tubulocystic carcinoma of the kidney with poorly differentiated foci

T2 - A series of 3 cases with fluorescence in situ hybridization analysis

AU - Al-Hussain, Turki O.

AU - Cheng, Liang

AU - Zhang, Shaobo

AU - Epstein, Jonathan I.

PY - 2013/7

Y1 - 2013/7

N2 - We identified 3 consult cases of tubulocystic renal cell carcinoma with poorly differentiated areas. Two lesions measuring 9.5 and 3.8 cm were described as partly solid and cystic. One case was grossly a 14.0-cm cyst with a granular lining. Microscopically, all had classic areas of circumscribed tubulocystic renal cell carcinoma occupying 30%, 80%, and 90% of the tumor; 2 cases had small components of papillary renal cell carcinoma, and 1 case had a central large cystic component. In 2 cases, proliferations of small tubules infiltrated away from the main mass with typical features of collecting duct carcinoma. In the third case, a focus of poorly differentiated carcinoma was seen adjacent to the tubulocystic renal cell carcinoma. In 2 cases, tumor invaded perirenal tissue. The third case was organ confined with vascular invasion. One patient died 9 months postoperatively with metastases to the abdominal wall and femur. The second case developed a recurrence in the renal bed 3 years postoperatively. The third patient was lost to follow-up. Fluorescence in situ hybridization studies results showed some features overlapping with papillary renal cell carcinoma in both the tubulocystic and collecting duct-like components and with 1 exception showed identical cytogenetic findings between the 2 components. Morphologically, in 2 cases, the collecting duct-like areas were also indistinguishable from collecting duct carcinoma suggesting a relationship between the 2 entities. This is the first series and only the second report of tubulocystic renal cell carcinoma with poorly differentiated components and documents the increased the risk of aggressive behavior above that of usual tubulocystic renal cell carcinoma.

AB - We identified 3 consult cases of tubulocystic renal cell carcinoma with poorly differentiated areas. Two lesions measuring 9.5 and 3.8 cm were described as partly solid and cystic. One case was grossly a 14.0-cm cyst with a granular lining. Microscopically, all had classic areas of circumscribed tubulocystic renal cell carcinoma occupying 30%, 80%, and 90% of the tumor; 2 cases had small components of papillary renal cell carcinoma, and 1 case had a central large cystic component. In 2 cases, proliferations of small tubules infiltrated away from the main mass with typical features of collecting duct carcinoma. In the third case, a focus of poorly differentiated carcinoma was seen adjacent to the tubulocystic renal cell carcinoma. In 2 cases, tumor invaded perirenal tissue. The third case was organ confined with vascular invasion. One patient died 9 months postoperatively with metastases to the abdominal wall and femur. The second case developed a recurrence in the renal bed 3 years postoperatively. The third patient was lost to follow-up. Fluorescence in situ hybridization studies results showed some features overlapping with papillary renal cell carcinoma in both the tubulocystic and collecting duct-like components and with 1 exception showed identical cytogenetic findings between the 2 components. Morphologically, in 2 cases, the collecting duct-like areas were also indistinguishable from collecting duct carcinoma suggesting a relationship between the 2 entities. This is the first series and only the second report of tubulocystic renal cell carcinoma with poorly differentiated components and documents the increased the risk of aggressive behavior above that of usual tubulocystic renal cell carcinoma.

KW - Collecting duct carcinoma

KW - Papillary renal cell carcinoma

KW - Renal cell carcinoma

KW - Tubulocystic carcinoma

UR - http://www.scopus.com/inward/record.url?scp=84879230839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879230839&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2012.11.015

DO - 10.1016/j.humpath.2012.11.015

M3 - Article

VL - 44

SP - 1406

EP - 1411

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 7

ER -