Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma

Thu Tran, Carol L. Jones, Sean R. Williamson, John Eble, David Grignon, Shaobo Zhang, Mingsheng Wang, Lee Ann Baldridge, Lisha Wang, Rodolfo Montironi, Marina Scarpelli, Puay Hoon Tan, Novae B. Simper, Eva Comperat, Liang Cheng

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aims: Some studies have suggested that tubulocystic carcinoma may be related to papillary renal cell carcinoma. We sought to compare and contrast the molecular and immunohistochemical profiles of tubulocystic carcinoma with those of papillary renal cell carcinoma. Methods and results: Twelve cases of pure tubulocystic renal cell carcinoma were subjected to fluorescence in-situ hybridization assessment of chromosomal number for chromosomes 7 and 17, and for TFE3 translocation. Immunohistochemical labelling for AMACR, p63, cytokeratin 7, PAX8, cytokeratin 20 and carbonic anhydrase IX was assessed in all tumours. No tumour showed gains of chromosomes 7 or 17, or TFE3 translocation by fluorescence in-situ hybridization. Immunohistochemistry revealed all tumours to be non-reactive with antibodies against p63 and cytokeratin 20. Conversely, the antibody against AMACR gave a positive reaction in the neoplastic cells of all tumours. Four tumours showed focal labelling with antibody against carbonic anhydrase IX, and five tumours showed focally positive reactions with antibody against cytokeratin 7. Recurrence and metastatic disease were not found for the patients with available follow-up information. Conclusions: Pure tubulocystic renal cell carcinoma is an indolent tumour with a good prognosis. Our data support the distinction of this neoplasm as a separate entity.

Original languageEnglish (US)
JournalHistopathology
DOIs
StateAccepted/In press - 2015

Fingerprint

Renal Cell Carcinoma
Neoplasms
Keratin-20
Keratin-7
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 7
Antibodies
Fluorescence In Situ Hybridization
Carcinoma
Immunohistochemistry
Recurrence

Keywords

  • Fluorescence in-situ hybridization
  • Immunohistochemistry
  • Kidney
  • Papillary renal cell carcinoma
  • Tubulocystic renal cell carcinoma

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma. / Tran, Thu; Jones, Carol L.; Williamson, Sean R.; Eble, John; Grignon, David; Zhang, Shaobo; Wang, Mingsheng; Baldridge, Lee Ann; Wang, Lisha; Montironi, Rodolfo; Scarpelli, Marina; Tan, Puay Hoon; Simper, Novae B.; Comperat, Eva; Cheng, Liang.

In: Histopathology, 2015.

Research output: Contribution to journalArticle

Tran, Thu ; Jones, Carol L. ; Williamson, Sean R. ; Eble, John ; Grignon, David ; Zhang, Shaobo ; Wang, Mingsheng ; Baldridge, Lee Ann ; Wang, Lisha ; Montironi, Rodolfo ; Scarpelli, Marina ; Tan, Puay Hoon ; Simper, Novae B. ; Comperat, Eva ; Cheng, Liang. / Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma. In: Histopathology. 2015.
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abstract = "Aims: Some studies have suggested that tubulocystic carcinoma may be related to papillary renal cell carcinoma. We sought to compare and contrast the molecular and immunohistochemical profiles of tubulocystic carcinoma with those of papillary renal cell carcinoma. Methods and results: Twelve cases of pure tubulocystic renal cell carcinoma were subjected to fluorescence in-situ hybridization assessment of chromosomal number for chromosomes 7 and 17, and for TFE3 translocation. Immunohistochemical labelling for AMACR, p63, cytokeratin 7, PAX8, cytokeratin 20 and carbonic anhydrase IX was assessed in all tumours. No tumour showed gains of chromosomes 7 or 17, or TFE3 translocation by fluorescence in-situ hybridization. Immunohistochemistry revealed all tumours to be non-reactive with antibodies against p63 and cytokeratin 20. Conversely, the antibody against AMACR gave a positive reaction in the neoplastic cells of all tumours. Four tumours showed focal labelling with antibody against carbonic anhydrase IX, and five tumours showed focally positive reactions with antibody against cytokeratin 7. Recurrence and metastatic disease were not found for the patients with available follow-up information. Conclusions: Pure tubulocystic renal cell carcinoma is an indolent tumour with a good prognosis. Our data support the distinction of this neoplasm as a separate entity.",
keywords = "Fluorescence in-situ hybridization, Immunohistochemistry, Kidney, Papillary renal cell carcinoma, Tubulocystic renal cell carcinoma",
author = "Thu Tran and Jones, {Carol L.} and Williamson, {Sean R.} and John Eble and David Grignon and Shaobo Zhang and Mingsheng Wang and Baldridge, {Lee Ann} and Lisha Wang and Rodolfo Montironi and Marina Scarpelli and Tan, {Puay Hoon} and Simper, {Novae B.} and Eva Comperat and Liang Cheng",
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T1 - Tubulocystic renal cell carcinoma is an entity that is immunohistochemically and genetically distinct from papillary renal cell carcinoma

AU - Tran, Thu

AU - Jones, Carol L.

AU - Williamson, Sean R.

AU - Eble, John

AU - Grignon, David

AU - Zhang, Shaobo

AU - Wang, Mingsheng

AU - Baldridge, Lee Ann

AU - Wang, Lisha

AU - Montironi, Rodolfo

AU - Scarpelli, Marina

AU - Tan, Puay Hoon

AU - Simper, Novae B.

AU - Comperat, Eva

AU - Cheng, Liang

PY - 2015

Y1 - 2015

N2 - Aims: Some studies have suggested that tubulocystic carcinoma may be related to papillary renal cell carcinoma. We sought to compare and contrast the molecular and immunohistochemical profiles of tubulocystic carcinoma with those of papillary renal cell carcinoma. Methods and results: Twelve cases of pure tubulocystic renal cell carcinoma were subjected to fluorescence in-situ hybridization assessment of chromosomal number for chromosomes 7 and 17, and for TFE3 translocation. Immunohistochemical labelling for AMACR, p63, cytokeratin 7, PAX8, cytokeratin 20 and carbonic anhydrase IX was assessed in all tumours. No tumour showed gains of chromosomes 7 or 17, or TFE3 translocation by fluorescence in-situ hybridization. Immunohistochemistry revealed all tumours to be non-reactive with antibodies against p63 and cytokeratin 20. Conversely, the antibody against AMACR gave a positive reaction in the neoplastic cells of all tumours. Four tumours showed focal labelling with antibody against carbonic anhydrase IX, and five tumours showed focally positive reactions with antibody against cytokeratin 7. Recurrence and metastatic disease were not found for the patients with available follow-up information. Conclusions: Pure tubulocystic renal cell carcinoma is an indolent tumour with a good prognosis. Our data support the distinction of this neoplasm as a separate entity.

AB - Aims: Some studies have suggested that tubulocystic carcinoma may be related to papillary renal cell carcinoma. We sought to compare and contrast the molecular and immunohistochemical profiles of tubulocystic carcinoma with those of papillary renal cell carcinoma. Methods and results: Twelve cases of pure tubulocystic renal cell carcinoma were subjected to fluorescence in-situ hybridization assessment of chromosomal number for chromosomes 7 and 17, and for TFE3 translocation. Immunohistochemical labelling for AMACR, p63, cytokeratin 7, PAX8, cytokeratin 20 and carbonic anhydrase IX was assessed in all tumours. No tumour showed gains of chromosomes 7 or 17, or TFE3 translocation by fluorescence in-situ hybridization. Immunohistochemistry revealed all tumours to be non-reactive with antibodies against p63 and cytokeratin 20. Conversely, the antibody against AMACR gave a positive reaction in the neoplastic cells of all tumours. Four tumours showed focal labelling with antibody against carbonic anhydrase IX, and five tumours showed focally positive reactions with antibody against cytokeratin 7. Recurrence and metastatic disease were not found for the patients with available follow-up information. Conclusions: Pure tubulocystic renal cell carcinoma is an indolent tumour with a good prognosis. Our data support the distinction of this neoplasm as a separate entity.

KW - Fluorescence in-situ hybridization

KW - Immunohistochemistry

KW - Kidney

KW - Papillary renal cell carcinoma

KW - Tubulocystic renal cell carcinoma

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