Tumor heterogeneity in breast cancer

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Tumor heterogeneity is the topic de jour, partly because molecular biologists and researchers are identifying it using sophisticated gene/DNA analysis techniques. Clinicians and pathologists are well acquainted with marked variability in clinical presentations, tumor histology, and, more importantly, clinical outcomes of their patients. In this review, we address these issues head-on and document that tumor heterogeneity is an old friend (or, more correctly, a foe). We described heterogeneity that exists at all levels-clinical, histologic, and molecular- and briefly outline the strategies that have been used by clinicians and pathologists to tackle this complicated issue.

Original languageEnglish (US)
Pages (from-to)294-302
Number of pages9
JournalAdvances in Anatomic Pathology
Volume22
Issue number5
StatePublished - Aug 1 2015

Keywords

  • Breast
  • Cancer
  • Pathology
  • Tumor heterogeneity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy

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