Phosphate plays a critical part in the regulation of cell metabolism, and phosphate homeostasis is closely regulated in normal humans. Indeed, like serum calcium, serum phosphate is maintained within a narrow range of values, and people with abnormal concentrations may have a predisposition to life-threatening conditions, such as hemolysis, myopathy, hypocalcemia, and nephrocalcinosis. The principal organ that regulates phosphate homeostasis is the kidney. Regulation is accomplished partly through variation in glomerular filtration of phosphate but primarily through variation in renal tubular reabsorption of phosphate. These variations are detectable within 24 hours after a change in dietary phosphate intake and even.
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