Tumor necrosis factor-α/receptor signaling through the Akt kinase

Osman Nidai Ozes, Hakan Akca, Jason A. Gustin, Lindsey D. Mayo, Roxana Pincheira, Chandrashekhar K. Korgaonkar, David B. Donner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Tumor necrosis factor (TNF) is a pleiotropic cytokine that can affect the growth, differentiation, and metabolism of virtually every nucleated cell type in the body. TNF promotes immunity, but its expression is also associated with pathologies, such as rheumatoid arthritis, type II diabetes, and cachexia. Two distinct cell-surface receptors bind TNF, the type I receptor (TNFR1), which contains a conserved motif called a death domain in its C-terminus, and the type II receptor. Binding of TNF to TNFR1 brings the death domains of TNFR1 into physical proximity, thereby promoting their interactions with cytoplasmic proteins that also contain death domains. Thus, a signal transduction cascade is initiated that coincidentally activates caspases that promote cell death and, additionally, anti-apoptotic events. The balance between these arms of the TNFR1 signaling cascade determines whether cells live or die.

Original languageEnglish (US)
Title of host publicationCell Signaling in Vascular Inflammation
PublisherHumana Press
Pages13-22
Number of pages10
ISBN (Print)1588295257, 9781588295255
DOIs
StatePublished - Dec 1 2005

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Keywords

  • acute-phase response
  • Akt serine-threonine kinase
  • apoptosis
  • immunity
  • nuclear factor kappa B
  • phosphatidylinositol 3-kinase
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ozes, O. N., Akca, H., Gustin, J. A., Mayo, L. D., Pincheira, R., Korgaonkar, C. K., & Donner, D. B. (2005). Tumor necrosis factor-α/receptor signaling through the Akt kinase. In Cell Signaling in Vascular Inflammation (pp. 13-22). Humana Press. https://doi.org/10.1007/978-1-59259-909-7_2