Tumor necrosis factor-α/receptor signaling through the Akt kinase

Osman Nidai Ozes, Hakan Akca, Jason A. Gustin, Lindsey Mayo, Roxana Pincheira, Chandrashekhar K. Korgaonkar, David B. Donner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Tumor necrosis factor (TNF) is a pleiotropic cytokine that can affect the growth, differentiation, and metabolism of virtually every nucleated cell type in the body. TNF promotes immunity, but its expression is also associated with pathologies, such as rheumatoid arthritis, type II diabetes, and cachexia. Two distinct cell-surface receptors bind TNF, the type I receptor (TNFR1), which contains a conserved motif called a death domain in its C-terminus, and the type II receptor. Binding of TNF to TNFR1 brings the death domains of TNFR1 into physical proximity, thereby promoting their interactions with cytoplasmic proteins that also contain death domains. Thus, a signal transduction cascade is initiated that coincidentally activates caspases that promote cell death and, additionally, anti-apoptotic events. The balance between these arms of the TNFR1 signaling cascade determines whether cells live or die.

Original languageEnglish
Title of host publicationCell Signaling in Vascular Inflammation
PublisherHumana Press
Pages13-22
Number of pages10
ISBN (Print)1588295257, 9781588295255
DOIs
StatePublished - 2005

Fingerprint

Receptors, Tumor Necrosis Factor, Type I
Tumor Necrosis Factor Receptors
Phosphotransferases
Tumor Necrosis Factor-alpha
Cachexia
Cell Surface Receptors
Caspases
Type 2 Diabetes Mellitus
Immunity
Signal Transduction
Rheumatoid Arthritis
Cell Death
Pathology
Cytokines
Growth
Death Domain
Proteins

Keywords

  • acute-phase response
  • Akt serine-threonine kinase
  • apoptosis
  • immunity
  • nuclear factor kappa B
  • phosphatidylinositol 3-kinase
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ozes, O. N., Akca, H., Gustin, J. A., Mayo, L., Pincheira, R., Korgaonkar, C. K., & Donner, D. B. (2005). Tumor necrosis factor-α/receptor signaling through the Akt kinase. In Cell Signaling in Vascular Inflammation (pp. 13-22). Humana Press. https://doi.org/10.1007/978-1-59259-909-7_2

Tumor necrosis factor-α/receptor signaling through the Akt kinase. / Ozes, Osman Nidai; Akca, Hakan; Gustin, Jason A.; Mayo, Lindsey; Pincheira, Roxana; Korgaonkar, Chandrashekhar K.; Donner, David B.

Cell Signaling in Vascular Inflammation. Humana Press, 2005. p. 13-22.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ozes, ON, Akca, H, Gustin, JA, Mayo, L, Pincheira, R, Korgaonkar, CK & Donner, DB 2005, Tumor necrosis factor-α/receptor signaling through the Akt kinase. in Cell Signaling in Vascular Inflammation. Humana Press, pp. 13-22. https://doi.org/10.1007/978-1-59259-909-7_2
Ozes ON, Akca H, Gustin JA, Mayo L, Pincheira R, Korgaonkar CK et al. Tumor necrosis factor-α/receptor signaling through the Akt kinase. In Cell Signaling in Vascular Inflammation. Humana Press. 2005. p. 13-22 https://doi.org/10.1007/978-1-59259-909-7_2
Ozes, Osman Nidai ; Akca, Hakan ; Gustin, Jason A. ; Mayo, Lindsey ; Pincheira, Roxana ; Korgaonkar, Chandrashekhar K. ; Donner, David B. / Tumor necrosis factor-α/receptor signaling through the Akt kinase. Cell Signaling in Vascular Inflammation. Humana Press, 2005. pp. 13-22
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