Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

D. M. Williams, Lynda Bonewald, G. David Roodman, G. I. Byrne, D. M. Magee, J. Schachter

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

A mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent) was used to demonstrate that whole spleen cells from both nude athymic mice (nu/nu) and heterozygous mice (nu/+) produced tumor necrosis factor alpha in vitro in response to mouse pneumonitis agent antigen. The tumor necrosis factor alpha measured in these supernatants by immunoassay was shown to have bioactivity in a cytotoxic assay in which uninfected target cells were used. This cytotoxicity was distinct from the gamma interferon-related cytotoxicity against C. trachomatis-infected targets that we described previously.

Original languageEnglish
Pages (from-to)1351-1355
Number of pages5
JournalInfection and Immunity
Volume57
Issue number5
StatePublished - 1989
Externally publishedYes

Fingerprint

Chlamydia Infections
Chlamydia trachomatis
Cytotoxins
Tumor Necrosis Factor-alpha
Pneumonia
Nude Mice
Immunoassay
Interferon-gamma
Spleen
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection. / Williams, D. M.; Bonewald, Lynda; Roodman, G. David; Byrne, G. I.; Magee, D. M.; Schachter, J.

In: Infection and Immunity, Vol. 57, No. 5, 1989, p. 1351-1355.

Research output: Contribution to journalArticle

Williams, D. M. ; Bonewald, Lynda ; Roodman, G. David ; Byrne, G. I. ; Magee, D. M. ; Schachter, J. / Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection. In: Infection and Immunity. 1989 ; Vol. 57, No. 5. pp. 1351-1355.
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