Tumor necrosis factor alpha is a cytotoxin induced by murine Chlamydia trachomatis infection

D. M. Williams, L. F. Bonewald, G. D. Roodman, G. I. Byrne, D. M. Magee, J. Schachter

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

A mouse model of pneumonia caused by murine Chlamydia trachomatis (mouse pneumonitis agent) was used to demonstrate that whole spleen cells from both nude athymic mice (nu/nu) and heterozygous mice (nu/+) produced tumor necrosis factor alpha in vitro in response to mouse pneumonitis agent antigen. The tumor necrosis factor alpha measured in these supernatants by immunoassay was shown to have bioactivity in a cytotoxic assay in which uninfected target cells were used. This cytotoxicity was distinct from the gamma interferon-related cytotoxicity against C. trachomatis-infected targets that we described previously.

Original languageEnglish (US)
Pages (from-to)1351-1355
Number of pages5
JournalInfection and immunity
Volume57
Issue number5
StatePublished - 1989

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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