Tumor suppressor gene expression during normal and pathologic myoeardial growth

Kyung Keun Kim, Mark Soonpaa, Adil I. Daud, Gou Young Koh, Jin Sang Kim, Loren Field

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Previous studies have identified several host proteins (p53, p107, and p193), which form prominent complexes with SV40 T antigen in transformed cardiomyocytes. Expression of p53 and p107 was monitored during normal and pathologic growth in nontransformed murine myocardium. Both genes were expressed at relatively high levels in embryonic cardiomyocytes. Transcript levels decreased markedly during the process of cardiomyocyte terminal differentiation and were very low or undetectable in adult animals. In contrast, retinoblastoma transcripts were observed at low levels throughout myocardial development. None of the tumor suppressor genes examined were transcriptionally activated during acute myocardial overload or isoproterenol-induced myocardial hypertrophy. The potential role of tumor suppressor gene product expression in myocardial development and pathology is discussed.

Original languageEnglish
Pages (from-to)22607-22613
Number of pages7
JournalJournal of Biological Chemistry
Volume269
Issue number36
StatePublished - Sep 9 1994

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Tumor Suppressor Genes
Cardiac Myocytes
Gene expression
Tumors
Genes
Gene Expression
Growth
Polyomavirus Transforming Antigens
Retinoblastoma
Pathology
Isoproterenol
Hypertrophy
Myocardium
Animals
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

Tumor suppressor gene expression during normal and pathologic myoeardial growth. / Kim, Kyung Keun; Soonpaa, Mark; Daud, Adil I.; Koh, Gou Young; Kim, Jin Sang; Field, Loren.

In: Journal of Biological Chemistry, Vol. 269, No. 36, 09.09.1994, p. 22607-22613.

Research output: Contribution to journalArticle

Kim, Kyung Keun ; Soonpaa, Mark ; Daud, Adil I. ; Koh, Gou Young ; Kim, Jin Sang ; Field, Loren. / Tumor suppressor gene expression during normal and pathologic myoeardial growth. In: Journal of Biological Chemistry. 1994 ; Vol. 269, No. 36. pp. 22607-22613.
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