Tumor viruses, oncogenes, and human cancer

Elliot J. Androphy, Douglas R. Lowy

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We review the biology of transforming retroviruses and their relationship to cellular transforming genes (tumor oncogenes). Evidence is discussed for the involvement of a retrovirus in a newly described syndrome, “adult T cell leukemia/lymphoma,” which has a high incidence of skin involvement. This virus is related to the animal retroviruses which induce tumors in susceptible hosts after a long latent period. Cellular transforming genes encode proteins which directly change the oncogenic potential of a cell. These genes, which are altered forms of normal cellular genes, have been isolated from a wide variety of human tumors. Viral and cellular transforming genes produce their changes by at least two different mechanisms: abnormally high production of the normal protein encoded by these genes, or normal levels of an altered form of the protein.

Original languageEnglish (US)
Pages (from-to)125-141
Number of pages17
JournalJournal of the American Academy of Dermatology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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