Tumors of the biliary tract

Michael G. House, Keith D. Lillemoe

Research output: Chapter in Book/Report/Conference proceedingChapter


Most tumors of the biliary tract are malignant and cause symptoms or signs of obstructive jaundice, liver dysfunction, or abdominal pain associated with weight loss. Cancers of the biliary tract are grouped into four major categories: gallbladder cancer, intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma, and distal cholangiocarcinoma. Major predisposing risk factors for the development of bile duct cancer (cholangiocarcinoma) include chronic inflammatory or infectious conditions and exposure to a carcinogen. Clinical assessment and cross-sectional radiographic imaging with computed tomography and magnetic resonance are mainstay diagnostic tools for the diagnosis and staging of bile duct tumors. Tissue acquisition for histologic or cytopathologic analysis prior to surgical resection remains challenging despite recent major advances in biliary tract examination and molecular testing.

Original languageEnglish (US)
Title of host publicationHandbook of Liver Disease
Number of pages14
ISBN (Electronic)9780323478823
ISBN (Print)9780323478748
StatePublished - Jan 1 2018


  • Bile duct cancer
  • Gallbladder cancer
  • Intrahepatic
  • Perihilar, and distal cholangiocarcinoma

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    House, M. G., & Lillemoe, K. D. (2018). Tumors of the biliary tract. In Handbook of Liver Disease (pp. 499-512). Elsevier. https://doi.org/10.1016/B978-0-323-47874-8.00036-5