Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma

Vital P. Costa, Jesus Jimenez-Roman, Felix Gil Carrasco, Alvaro Lupinacci, Alon Harris

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aim: To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals. Methods: 24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device. Results: Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05). Conclusion Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.

Original languageEnglish
Pages (from-to)1291-1294
Number of pages4
JournalBritish Journal of Ophthalmology
Volume94
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Perfusion
Pressure
Blood Pressure
Intraocular Pressure
Supine Position
Primary Open Angle Glaucoma
Equipment and Supplies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma. / Costa, Vital P.; Jimenez-Roman, Jesus; Carrasco, Felix Gil; Lupinacci, Alvaro; Harris, Alon.

In: British Journal of Ophthalmology, Vol. 94, No. 10, 10.2010, p. 1291-1294.

Research output: Contribution to journalArticle

Costa, Vital P. ; Jimenez-Roman, Jesus ; Carrasco, Felix Gil ; Lupinacci, Alvaro ; Harris, Alon. / Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma. In: British Journal of Ophthalmology. 2010 ; Vol. 94, No. 10. pp. 1291-1294.
@article{51928e0684fc480fbcfce7b4a47de2a5,
title = "Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma",
abstract = "Aim: To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals. Methods: 24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device. Results: Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05). Conclusion Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.",
author = "Costa, {Vital P.} and Jesus Jimenez-Roman and Carrasco, {Felix Gil} and Alvaro Lupinacci and Alon Harris",
year = "2010",
month = "10",
doi = "10.1136/bjo.2009.167569",
language = "English",
volume = "94",
pages = "1291--1294",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "10",

}

TY - JOUR

T1 - Twenty-four-hour ocular perfusion pressure in primary open-angle glaucoma

AU - Costa, Vital P.

AU - Jimenez-Roman, Jesus

AU - Carrasco, Felix Gil

AU - Lupinacci, Alvaro

AU - Harris, Alon

PY - 2010/10

Y1 - 2010/10

N2 - Aim: To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals. Methods: 24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device. Results: Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05). Conclusion Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.

AB - Aim: To compare the 24 h intraocular pressure (IOP), blood pressure (BP), and perfusion pressure (PP) of primary open-angle glaucoma (POAG) patients and healthy individuals. Methods: 24 healthy individuals and 29 POAG patients underwent IOP and BP measurements every 2 h, starting at 08:00 until 06:00 of the next morning. IOP measurements were made by a masked observer with a Goldmann tonometer at the slit-lamp from 08:00 to 22:00 and with the Perkins tonometer in supine position from 24:00 to 06:00. Systolic and diastolic BP (SBP and DBP) measurements were performed with an automated device. Results: Mean IOPs in POAG patients were significantly higher at all time intervals (p<0.001). The mean SBP was significantly higher in POAG patients from 04:00 to 10:00, and also at 14:00 and 18:00 (p<0.05). In POAG patients, the mean DBP was significantly higher at 08:00 and 10:00, but was significantly lower at 04:00 (p<0.05). In POAG patients, the mean systolic perfusion pressure (SPP) was significantly higher at 08:00 and 10:00 (p<0.01), whereas the mean diastolic perfusion pressure (DPP) was significantly lower from 24:00 to 06:00 (p<0.05). Conclusion Although higher SPPs are observed in POAG patients during the morning, lower DPPs are found during the night.

UR - http://www.scopus.com/inward/record.url?scp=77958616563&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958616563&partnerID=8YFLogxK

U2 - 10.1136/bjo.2009.167569

DO - 10.1136/bjo.2009.167569

M3 - Article

VL - 94

SP - 1291

EP - 1294

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 10

ER -