Two children with both arm ischemia and arterial ischemic stroke during the perinatal period

Marilyn J. McKasson, Meredith Golomb

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It is rare for both limb ischemia and arterial ischemic stroke to occur in the same child during the perinatal period. Two children who appear to have had perinatal emboli to both an arm and a middle cerebral artery territory are presented here. One child required amputation of the ischemic limb below the shoulder, and the other required skin grafts to the distal ischemic fingers. Each of these children later received cerebral magnetic resonance imaging for evaluation of developmental delay and was found to have what appeared to be old perinatal arterial ischemic stroke. Both children were homozygous for the methylenetetrahydrofolate reductase C677T gene variant. Eight other children with perinatal limb ischemia and stroke were found on literature review; several also had delayed diagnosis of perinatal stroke. This report examines the approach to diagnosis and treatment in each of these and makes suggestions for the similar cases in the future.

Original languageEnglish
Pages (from-to)1548-1554
Number of pages7
JournalJournal of Child Neurology
Volume26
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

Arm
Ischemia
Stroke
Extremities
Methylenetetrahydrofolate Reductase (NADPH2)
Delayed Diagnosis
Middle Cerebral Artery
Embolism
Amputation
Fingers
Magnetic Resonance Imaging
Transplants
Skin
Genes
Therapeutics

Keywords

  • emboli
  • extremity ischemia
  • perinatal
  • stroke
  • thromboembolism

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Two children with both arm ischemia and arterial ischemic stroke during the perinatal period. / McKasson, Marilyn J.; Golomb, Meredith.

In: Journal of Child Neurology, Vol. 26, No. 12, 12.2011, p. 1548-1554.

Research output: Contribution to journalArticle

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