Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans

Mark W. Logue, Matthew Schu, Badri N. Vardarajan, John Farrell, David A. Bennett, Joseph D. Buxbaum, Goldie S. Byrd, Nilufer Ertekin-Taner, Denis Evans, Tatiana Foroud, Alison Goate, Neill R. Graff-Radford, M. Ilyas Kamboh, Walter A. Kukull, Jennifer J. Manly, Jonathan L. Hainesm, Richard Mayeuxl, Margaret A. Pericak-Vancen, Gerard D. Schellenbergo, Kathryn L. LunettabClinton T. Baldwina, M. Daniele Fallinp, Lindsay A. Farrer

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background Less is known about the genetic basis of Alzheimer's disease (AD) in African Americans (AAs) than in non-Hispanic whites. Methods Whole exome sequencing (WES) was performed on seven AA AD cases. Disease association with potentially AD-related variants from WES was assessed in an AA discovery cohort of 422 cases and 394 controls. Replication was sought in an AA sample of 1037 cases and 1869 controls from the Alzheimer Disease Genetics Consortium (ADGC). Results Forty-four single nucleotide polymorphisms (SNPs) from WES passed filtering criteria and were successfully genotyped. Nominally significant (P

Original languageEnglish (US)
Pages (from-to)609-618
Number of pages10
JournalAlzheimer's and Dementia
Volume10
Issue number6
DOIs
StatePublished - Nov 1 2014

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Exome
African Americans
Alzheimer Disease
Single Nucleotide Polymorphism

Keywords

  • African American
  • AKAP9
  • Genetic association
  • Late-onset Alzheimer's disease
  • Rare variant
  • Whole-exome sequencing

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Logue, M. W., Schu, M., Vardarajan, B. N., Farrell, J., Bennett, D. A., Buxbaum, J. D., ... Farrer, L. A. (2014). Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimer's and Dementia, 10(6), 609-618. https://doi.org/10.1016/j.jalz.2014.06.010

Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. / Logue, Mark W.; Schu, Matthew; Vardarajan, Badri N.; Farrell, John; Bennett, David A.; Buxbaum, Joseph D.; Byrd, Goldie S.; Ertekin-Taner, Nilufer; Evans, Denis; Foroud, Tatiana; Goate, Alison; Graff-Radford, Neill R.; Kamboh, M. Ilyas; Kukull, Walter A.; Manly, Jennifer J.; Hainesm, Jonathan L.; Mayeuxl, Richard; Pericak-Vancen, Margaret A.; Schellenbergo, Gerard D.; Lunettab, Kathryn L.; Baldwina, Clinton T.; Daniele Fallinp, M.; Farrer, Lindsay A.

In: Alzheimer's and Dementia, Vol. 10, No. 6, 01.11.2014, p. 609-618.

Research output: Contribution to journalArticle

Logue, MW, Schu, M, Vardarajan, BN, Farrell, J, Bennett, DA, Buxbaum, JD, Byrd, GS, Ertekin-Taner, N, Evans, D, Foroud, T, Goate, A, Graff-Radford, NR, Kamboh, MI, Kukull, WA, Manly, JJ, Hainesm, JL, Mayeuxl, R, Pericak-Vancen, MA, Schellenbergo, GD, Lunettab, KL, Baldwina, CT, Daniele Fallinp, M & Farrer, LA 2014, 'Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans', Alzheimer's and Dementia, vol. 10, no. 6, pp. 609-618. https://doi.org/10.1016/j.jalz.2014.06.010
Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD et al. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimer's and Dementia. 2014 Nov 1;10(6):609-618. https://doi.org/10.1016/j.jalz.2014.06.010
Logue, Mark W. ; Schu, Matthew ; Vardarajan, Badri N. ; Farrell, John ; Bennett, David A. ; Buxbaum, Joseph D. ; Byrd, Goldie S. ; Ertekin-Taner, Nilufer ; Evans, Denis ; Foroud, Tatiana ; Goate, Alison ; Graff-Radford, Neill R. ; Kamboh, M. Ilyas ; Kukull, Walter A. ; Manly, Jennifer J. ; Hainesm, Jonathan L. ; Mayeuxl, Richard ; Pericak-Vancen, Margaret A. ; Schellenbergo, Gerard D. ; Lunettab, Kathryn L. ; Baldwina, Clinton T. ; Daniele Fallinp, M. ; Farrer, Lindsay A. / Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. In: Alzheimer's and Dementia. 2014 ; Vol. 10, No. 6. pp. 609-618.
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AU - Lunettab, Kathryn L.

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AU - Farrer, Lindsay A.

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