TXNIP switches tracks toward a terminal UPR

Tracy G. Anthony, Ronald Wek

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death.

Original languageEnglish
Pages (from-to)135-137
Number of pages3
JournalCell Metabolism
Volume16
Issue number2
DOIs
StatePublished - Aug 8 2012

Fingerprint

Inflammasomes
Unfolded Protein Response
Thioredoxins
Islets of Langerhans
Cell Death
Inflammation
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

TXNIP switches tracks toward a terminal UPR. / Anthony, Tracy G.; Wek, Ronald.

In: Cell Metabolism, Vol. 16, No. 2, 08.08.2012, p. 135-137.

Research output: Contribution to journalArticle

Anthony, Tracy G. ; Wek, Ronald. / TXNIP switches tracks toward a terminal UPR. In: Cell Metabolism. 2012 ; Vol. 16, No. 2. pp. 135-137.
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