TXNIP switches tracks toward a terminal UPR

Tracy G. Anthony, Ronald C. Wek

Research output: Contribution to journalShort survey

24 Scopus citations


During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death.

Original languageEnglish (US)
Pages (from-to)135-137
Number of pages3
JournalCell Metabolism
Issue number2
StatePublished - Aug 8 2012

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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