Type 1 diabetes

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.

Original languageEnglish (US)
Pages (from-to)2449-2462
Number of pages14
JournalThe Lancet
Volume391
Issue number10138
DOIs
StatePublished - Jun 16 2018

Fingerprint

Type 1 Diabetes Mellitus
Molecular Epidemiology
Disease Management
Hyperglycemia
Autoimmune Diseases
Chronic Disease
Insulin
Phenotype
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Type 1 diabetes. / DiMeglio, Linda; Evans-Molina, Carmella; Oram, Richard A.

In: The Lancet, Vol. 391, No. 10138, 16.06.2018, p. 2449-2462.

Research output: Contribution to journalReview article

DiMeglio, Linda ; Evans-Molina, Carmella ; Oram, Richard A. / Type 1 diabetes. In: The Lancet. 2018 ; Vol. 391, No. 10138. pp. 2449-2462.
@article{fe01f42e80bf4e7ca758c97bf34cfd6c,
title = "Type 1 diabetes",
abstract = "Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.",
author = "Linda DiMeglio and Carmella Evans-Molina and Oram, {Richard A.}",
year = "2018",
month = "6",
day = "16",
doi = "10.1016/S0140-6736(18)31320-5",
language = "English (US)",
volume = "391",
pages = "2449--2462",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "10138",

}

TY - JOUR

T1 - Type 1 diabetes

AU - DiMeglio, Linda

AU - Evans-Molina, Carmella

AU - Oram, Richard A.

PY - 2018/6/16

Y1 - 2018/6/16

N2 - Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.

AB - Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden. Interventions to preserve β cells have been tested, and several methods to improve clinical disease management have been assessed. However, wide gaps still exist in our understanding of type 1 diabetes and our ability to standardise clinical care and decrease disease-associated complications and burden. This Seminar gives an overview of the current understanding of the disease and potential future directions for research and care.

UR - http://www.scopus.com/inward/record.url?scp=85048387111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048387111&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(18)31320-5

DO - 10.1016/S0140-6736(18)31320-5

M3 - Review article

C2 - 29916386

AN - SCOPUS:85048387111

VL - 391

SP - 2449

EP - 2462

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 10138

ER -