Type 2 diabetes genetic risk scores are associated with increased type 2 diabetes risk among African Americans by cardiometabolic status

Jill Layton, Xiaochen Li, Changyu Shen, Mary de Groot, Leslie Lange, Adolfo Correa, Jennifer Wessel

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The relationship between genetic risk variants associated with glucose homeostasis and type 2 diabetes risk has yet to be fully explored in African American populations. We pooled data from 4 prospective studies including 4622 African Americans to assess whether β-cell dysfunction (BCD) and/or insulin resistance (IR) genetic variants were associated with increased type 2 diabetes risk. The BCD genetic risk score (GRS) and combined BCD/IR GRS were significantly associated with increased type 2 diabetes risk. In cardiometabolic-stratified models, the BCD and IR GRS were associated with increased type 2 diabetes risk among 5 cardiometabolic strata: 3 clinically healthy strata and 2 clinically unhealthy strata. Genetic risk scores related to BCD and IR were associated with increased risk of type 2 diabetes in African Americans. Notably, the GRSs were significant predictors of type 2 diabetes among individuals in clinically normal ranges of cardiometabolic traits.

Original languageEnglish (US)
JournalClinical Medicine Insights: Endocrinology and Diabetes
Volume11
DOIs
StatePublished - Jan 1 2018

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Keywords

  • African American health
  • Genetic epidemiology
  • Genetic risk factors
  • Risk prediction
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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