Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants

Wei Li, Shannon L. Risacher, Sujuan Gao, Stephen L. Boehm, Jeffrey S. Elmendorf, Andrew J. Saykin, Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

  • 3 Citations

Abstract

Introduction Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42. Methods Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ. Results CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF Aβ1-42 and cerebral cortical Aβ was independent of T2DM status. Participants with T2DM had a lower cerebral cortical Aβ in anterior cingulate, precuneus, and temporal lobe than controls. Discussion T2DM is positively associated with CSF Aβ1-42 but negatively with cerebral cortical Aβ. The decreased cerebral cortical Aβ associated with T2DM is preferentially located in certain brain regions.

LanguageEnglish (US)
Pages94-98
Number of pages5
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume10
DOIs
StatePublished - Jan 1 2018

Fingerprint

Amyloid
Neuroimaging
Type 2 Diabetes Mellitus
Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
Parietal Lobe
Gyrus Cinguli
Temporal Lobe
Databases
Brain

Keywords

  • Alzheimer's disease
  • Amyloid β
  • Aβ1-42
  • Cerebrospinal fluid (CSF)
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants. / Li, Wei; Risacher, Shannon L.; Gao, Sujuan; Boehm, Stephen L.; Elmendorf, Jeffrey S.; Saykin, Andrew J.; Alzheimer's Disease Neuroimaging Initiative.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 10, 01.01.2018, p. 94-98.

Research output: Contribution to journalArticle

@article{8bde339861ca4d46b7e964538bb0a9bd,
title = "Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants",
abstract = "Introduction Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42. Methods Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ. Results CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF Aβ1-42 and cerebral cortical Aβ was independent of T2DM status. Participants with T2DM had a lower cerebral cortical Aβ in anterior cingulate, precuneus, and temporal lobe than controls. Discussion T2DM is positively associated with CSF Aβ1-42 but negatively with cerebral cortical Aβ. The decreased cerebral cortical Aβ associated with T2DM is preferentially located in certain brain regions.",
keywords = "Alzheimer's disease, Amyloid β, Aβ1-42, Cerebrospinal fluid (CSF), Type 2 diabetes mellitus",
author = "Wei Li and Risacher, {Shannon L.} and Sujuan Gao and Boehm, {Stephen L.} and Elmendorf, {Jeffrey S.} and Saykin, {Andrew J.} and {Alzheimer's Disease Neuroimaging Initiative}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.dadm.2017.11.002",
language = "English (US)",
volume = "10",
pages = "94--98",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants

AU - Li,Wei

AU - Risacher,Shannon L.

AU - Gao,Sujuan

AU - Boehm,Stephen L.

AU - Elmendorf,Jeffrey S.

AU - Saykin,Andrew J.

AU - Alzheimer's Disease Neuroimaging Initiative

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42. Methods Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ. Results CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF Aβ1-42 and cerebral cortical Aβ was independent of T2DM status. Participants with T2DM had a lower cerebral cortical Aβ in anterior cingulate, precuneus, and temporal lobe than controls. Discussion T2DM is positively associated with CSF Aβ1-42 but negatively with cerebral cortical Aβ. The decreased cerebral cortical Aβ associated with T2DM is preferentially located in certain brain regions.

AB - Introduction Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42. Methods Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ. Results CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF Aβ1-42 and cerebral cortical Aβ was independent of T2DM status. Participants with T2DM had a lower cerebral cortical Aβ in anterior cingulate, precuneus, and temporal lobe than controls. Discussion T2DM is positively associated with CSF Aβ1-42 but negatively with cerebral cortical Aβ. The decreased cerebral cortical Aβ associated with T2DM is preferentially located in certain brain regions.

KW - Alzheimer's disease

KW - Amyloid β

KW - Aβ1-42

KW - Cerebrospinal fluid (CSF)

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=85036607886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85036607886&partnerID=8YFLogxK

U2 - 10.1016/j.dadm.2017.11.002

DO - 10.1016/j.dadm.2017.11.002

M3 - Article

VL - 10

SP - 94

EP - 98

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

T2 - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -