Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

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Introduction Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42. Methods Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ. Results CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF Aβ1-42 and cerebral cortical Aβ was independent of T2DM status. Participants with T2DM had a lower cerebral cortical Aβ in anterior cingulate, precuneus, and temporal lobe than controls. Discussion T2DM is positively associated with CSF Aβ1-42 but negatively with cerebral cortical Aβ. The decreased cerebral cortical Aβ associated with T2DM is preferentially located in certain brain regions.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
StatePublished - Jan 1 2018



  • Alzheimer's disease
  • Amyloid β
  • Aβ1-42
  • Cerebrospinal fluid (CSF)
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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