Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection

Li Jiang, Shuyu Yao, Su Huang, Jeffrey Wright, Thomas J. Braciale, Jie Sun

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Recent evidence has suggested that IL-10-producing effector CD8+ T cells play an important role in regulating excessive inflammation during acute viral infections. However, the cellular and molecular cues regulating the development of IL-10-producing effector CD8+ T cells are not completely defined. Here, we show that type I interferons (IFNs) are required for the development of IL-10-producing effector CD8+ T cells during influenza virus infection in mice. We find that type I IFNs can enhance IL-27 production by lung APCs, thereby facilitating IL-10-producing CD8+ T-cell development through a CD8+ T-cell-nonautonomous way. Surprisingly, we also demonstrate that direct type I IFN signaling in CD8+ T cells is required for the maximal generation of IL-10-producing CD8+ T cells. Type I IFN signaling in CD8+ T cells, in cooperation with IL-27 and IL-2 signaling, promotes and sustains the expression of IFN regulatory factor 4 (IRF4) and B-lymphocyte-induced maturation protein-1 (Blimp-1), two transcription factors required for the production of IL-10 by effector CD8+ T cells. Our data reveal a critical role of the innate antiviral effector cytokines in regulating the production of a regulatory cytokine by effector CD8+ T cells during respiratory virus infection.

Original languageEnglish (US)
Pages (from-to)2778-2788
Number of pages11
JournalEuropean Journal of Immunology
Volume46
Issue number12
DOIs
StatePublished - Dec 1 2016

Fingerprint

Interferon Type I
Virus Diseases
Orthomyxoviridae
Interleukin-10
T-Lymphocytes
Interleukin-27
Cytokines
Respiratory Tract Infections
Interleukin-2
Antiviral Agents
Cues
B-Lymphocytes
Transcription Factors
Inflammation
Lung

Keywords

  • CD8 T cells
  • IL-10
  • IL-27
  • Influenza
  • Type I IFN

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection. / Jiang, Li; Yao, Shuyu; Huang, Su; Wright, Jeffrey; Braciale, Thomas J.; Sun, Jie.

In: European Journal of Immunology, Vol. 46, No. 12, 01.12.2016, p. 2778-2788.

Research output: Contribution to journalArticle

Jiang, Li ; Yao, Shuyu ; Huang, Su ; Wright, Jeffrey ; Braciale, Thomas J. ; Sun, Jie. / Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection. In: European Journal of Immunology. 2016 ; Vol. 46, No. 12. pp. 2778-2788.
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