Tyr-W-MIF-1-induced conditioned place preference

William L. Noresa, Richard D. Olson, Gayle A. Olson, Anthony L. Vaccarino, Richard L. Bell, James E. Zadina, Abba J. Kastin

Research output: Contribution to journalArticle

8 Scopus citations


Based on the evidence that Tyr-Pro-Trp-Gly NH2 (Tyr-W-MIF-1) produced dose-dependent, μ-opiate agonistic/antagonistic effects, we investigated whether Tyr-W-MIF-1 exhibited similar properties in the conditioned place preference (CPP) test. To examine the opiate agonistic effects on CPP, rats were conditioned with alternating ICV injections of saline and Tyr-W-MIF-1 (0 or 200 μg). This procedure resulted in Tyr-W-MIF-1-induced CPP. To examine the opiate antagonistic properties of low doses of Tyr-W-MIF-1, morphine-induced CPP was challenged with Tyr-W-MIF-1 (0, 25, 50, or 100 μg). Morphine-induced CPP was not affected by Tyr-W-MIF-1 at these doses. These findings show that in the CPP test Tyr-W-MIF-1 produced opiate agonistic effects at the high dose and was without opiate antagonistic properties at lower doses. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)479-484
Number of pages6
Issue number4
StatePublished - May 1 1999
Externally publishedYes


  • Antagonist
  • Intracerebroventricular
  • Mixed agonist
  • Opiate
  • Opioid
  • Rats
  • Reward
  • Tyr-W-MIF-1

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Noresa, W. L., Olson, R. D., Olson, G. A., Vaccarino, A. L., Bell, R. L., Zadina, J. E., & Kastin, A. J. (1999). Tyr-W-MIF-1-induced conditioned place preference. Peptides, 20(4), 479-484. https://doi.org/10.1016/S0196-9781(99)00029-7