Tyr-W-MIF-1-induced conditioned place preference

William L. Noresa, Richard D. Olson, Gayle A. Olson, Anthony L. Vaccarino, Richard Bell, James E. Zadina, Abba J. Kastin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Based on the evidence that Tyr-Pro-Trp-Gly NH2 (Tyr-W-MIF-1) produced dose-dependent, μ-opiate agonistic/antagonistic effects, we investigated whether Tyr-W-MIF-1 exhibited similar properties in the conditioned place preference (CPP) test. To examine the opiate agonistic effects on CPP, rats were conditioned with alternating ICV injections of saline and Tyr-W-MIF-1 (0 or 200 μg). This procedure resulted in Tyr-W-MIF-1-induced CPP. To examine the opiate antagonistic properties of low doses of Tyr-W-MIF-1, morphine-induced CPP was challenged with Tyr-W-MIF-1 (0, 25, 50, or 100 μg). Morphine-induced CPP was not affected by Tyr-W-MIF-1 at these doses. These findings show that in the CPP test Tyr-W-MIF-1 produced opiate agonistic effects at the high dose and was without opiate antagonistic properties at lower doses. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)479-484
Number of pages6
JournalPeptides
Volume20
Issue number4
DOIs
StatePublished - May 1999
Externally publishedYes

Fingerprint

Opiate Alkaloids
Morphine
tyrosyl-prolyl-tryptophyl-glycinamide
Rats
Injections

Keywords

  • Antagonist
  • Intracerebroventricular
  • Mixed agonist
  • Opiate
  • Opioid
  • Rats
  • Reward
  • Tyr-W-MIF-1

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Noresa, W. L., Olson, R. D., Olson, G. A., Vaccarino, A. L., Bell, R., Zadina, J. E., & Kastin, A. J. (1999). Tyr-W-MIF-1-induced conditioned place preference. Peptides, 20(4), 479-484. https://doi.org/10.1016/S0196-9781(99)00029-7

Tyr-W-MIF-1-induced conditioned place preference. / Noresa, William L.; Olson, Richard D.; Olson, Gayle A.; Vaccarino, Anthony L.; Bell, Richard; Zadina, James E.; Kastin, Abba J.

In: Peptides, Vol. 20, No. 4, 05.1999, p. 479-484.

Research output: Contribution to journalArticle

Noresa, WL, Olson, RD, Olson, GA, Vaccarino, AL, Bell, R, Zadina, JE & Kastin, AJ 1999, 'Tyr-W-MIF-1-induced conditioned place preference', Peptides, vol. 20, no. 4, pp. 479-484. https://doi.org/10.1016/S0196-9781(99)00029-7
Noresa WL, Olson RD, Olson GA, Vaccarino AL, Bell R, Zadina JE et al. Tyr-W-MIF-1-induced conditioned place preference. Peptides. 1999 May;20(4):479-484. https://doi.org/10.1016/S0196-9781(99)00029-7
Noresa, William L. ; Olson, Richard D. ; Olson, Gayle A. ; Vaccarino, Anthony L. ; Bell, Richard ; Zadina, James E. ; Kastin, Abba J. / Tyr-W-MIF-1-induced conditioned place preference. In: Peptides. 1999 ; Vol. 20, No. 4. pp. 479-484.
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