Ubiquitin-dependent proteolysis and cell cycle control in yeast.

K. T. Chun, N. Mathias, M. G. Goebl

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Genetic and biochemical data indicate that ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression. In general, mutations in some genes that encode proteins involved in the ubiquitin pathway cause cell cycle defects and affect the turnover of cell cycle regulatory proteins. Furthermore, some cell cycle regulatory proteins are short-lived, ubiquitinated, and degraded by the ubiquitin pathway. This review will examine how the ubiquitin pathway plays a role in regulating progression from the G1 to the S phase of the cell cycle, as well as the G2 to M phase transition.

Original languageEnglish (US)
Pages (from-to)115-127
Number of pages13
JournalProgress in cell cycle research
Volume2
StatePublished - 1996

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ASJC Scopus subject areas

  • Medicine(all)

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