Ubiquitin ligases and posttranslational regulation of energy in the heart: The hand that feeds

David I. Brown, Traci L. Parry, Monte Willis

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Heart failure (HF) is a costly and deadly syndrome characterized by the reduced capacity of the heart to adequately provide systemic blood flow. Mounting evidence implicates pathological changes in cardiac energy metabolism as a contributing factor in the development of HF. While the main source of fuel in the healthy heart is the oxidation of fatty acids, in the failing heart the less energy efficient glucose and glycogen metabolism are upregulated. The ubiquitin proteasome system plays a key role in regulating metabolism via protein-degradation/regulation of autophagy and regulating metabolism-related transcription and cell signaling processes. In this review, we discuss recent research that describes the role of the ubiquitin-proteasome system (UPS) in regulating metabolism in the context of HF.We focus on ubiquitin ligases (E3s), the component of the UPS that confers substrate specificity, and detail the current understanding of how these E3s contribute to cardiac pathology and metabolism.

Original languageEnglish (US)
Pages (from-to)841-862
Number of pages22
JournalComprehensive Physiology
Volume7
Issue number3
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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