Ultracal-30 gypsum artificial stones for research on the mechanisms of stone breakage in shock wave lithotripsy

James A. McAteer, James Williams, Robin O. Cleveland, Javier Van Cauwelaert, Michael R. Bailey, David A. Lifshitz, Andrew Evan

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Artificial stones are used in research on the mechanisms of stone breakage in shock wave lithotripsy (SWL) and in assessing lithotripter performance. We have adopted Ultracal-30 gypsum as a model, finding it suitable for SWL studies in vitro, acute animal experiments in which stones are implanted in the kidney, and as a target to compare the in vitro performance of intracorporeal lithotripters. Here we describe the preparation of U-30 stones, their material properties, shock wave (SW) breakage characteristics, and methods used for quantitation of stone fragmentation with this model. Ultracal-30 gypsum cement was mixed 1:1 with water, cast in plastic multi-well plates, then, the stones were liberated by dissolving the plastic with chloroform and stored under water. Stone breakage in SWL was assessed by several methods including measures of the increase in projected surface area of SW-treated stones. Breakage of hydrated stones showed a linear increase in fragment area with increased SW-number and SW-voltage. Stones stored in water for an extended time showed reduced fragility. Dried stones could be rehydrated so that breakage was not different from stones that had never been dry, but stones rehydrated for less than 96 h showed increased fragility to SWs. The physical properties of U-30 stones place them in the range reported for natural stones. U-30 stones in vitro and in vivo showed equivalent response to SW-rate, with ∼200% greater fragmentation at 30 SW/min compared to 120 SW/min, suggesting that the mechanisms of SW action are similar under both conditions. U-30 stones provide a convenient, reproducible model for SWL research.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalUrological Research
Volume33
Issue number6
DOIs
StatePublished - Dec 2005

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Calcium Sulfate
Lithotripsy
Research
Water
Surgical Casts
Chloroform
Plastics
Kidney
In Vitro Techniques

Keywords

  • Biological models
  • Kidney calculi
  • Lithotripsy
  • Urinary calculi

ASJC Scopus subject areas

  • Urology

Cite this

Ultracal-30 gypsum artificial stones for research on the mechanisms of stone breakage in shock wave lithotripsy. / McAteer, James A.; Williams, James; Cleveland, Robin O.; Van Cauwelaert, Javier; Bailey, Michael R.; Lifshitz, David A.; Evan, Andrew.

In: Urological Research, Vol. 33, No. 6, 12.2005, p. 429-434.

Research output: Contribution to journalArticle

McAteer, James A. ; Williams, James ; Cleveland, Robin O. ; Van Cauwelaert, Javier ; Bailey, Michael R. ; Lifshitz, David A. ; Evan, Andrew. / Ultracal-30 gypsum artificial stones for research on the mechanisms of stone breakage in shock wave lithotripsy. In: Urological Research. 2005 ; Vol. 33, No. 6. pp. 429-434.
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