Ultrasound gel causes fine needle aspiration artifact? A clear choice

Mark C. Royer, Darrell D. Davidson, Rosen K. Dimitrov, Connie Y. Kuo, Mimi S. Kokoska

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Ultrasound-guided fine needle aspiration (FNA) is a commonly employed tool in cytopathologic practice. Artifacts resulting in misinterpretation of specimens have been noted with various ultrasound gel media. Our purpose was to perform a prospective human cadaveric study of this phenomenon to identify a low-cost solution that eliminates the artifact. Study Design: Three separate ultrasound-guided FNAs were performed on the thyroid and parotid glands in situ of a fresh human cadaver using three different types of ultrasound gel media. Slides were prepared in standard fashion (Quik-Diff and Papanicolaou stains). Two cytopathologists subsequently analyzed the slides for the presence of any artifact interfering with their ability to visualize and interpret the cellular aspirate material. Results: Two of the three gel media revealed significant artifacts mimicking apoptosis, necrosis or colloid, making it difficult to visualize the cellular components and differentiate the artifact from the thyroid colloid. One gel medium did not show any significant artifact, and there was no discernable difference in its quality with regard to the ultrasound image during FNA procedures. Conclusions: Ultrasound gels can be associated with a significant artifact in FNA specimens. To eliminate this artifact, which may alter the adequacy, diagnosis or cytologic appearance, we confirm a specific gel type that is useful for ultrasound-guided FNAs.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalActa Cytologica
Volume56
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Fine Needle Biopsy
Artifacts
Gels
Colloids
Thyroid Gland
Parotid Gland
Cadaver
Necrosis
Apoptosis
Costs and Cost Analysis

Keywords

  • Artifact
  • Fine needle aspiration
  • Parotid gland
  • Thyroid gland
  • Ultrasound gel

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Royer, M. C., Davidson, D. D., Dimitrov, R. K., Kuo, C. Y., & Kokoska, M. S. (2012). Ultrasound gel causes fine needle aspiration artifact? A clear choice. Acta Cytologica, 56(2), 146-154. https://doi.org/10.1159/000335484

Ultrasound gel causes fine needle aspiration artifact? A clear choice. / Royer, Mark C.; Davidson, Darrell D.; Dimitrov, Rosen K.; Kuo, Connie Y.; Kokoska, Mimi S.

In: Acta Cytologica, Vol. 56, No. 2, 02.2012, p. 146-154.

Research output: Contribution to journalArticle

Royer, MC, Davidson, DD, Dimitrov, RK, Kuo, CY & Kokoska, MS 2012, 'Ultrasound gel causes fine needle aspiration artifact? A clear choice', Acta Cytologica, vol. 56, no. 2, pp. 146-154. https://doi.org/10.1159/000335484
Royer MC, Davidson DD, Dimitrov RK, Kuo CY, Kokoska MS. Ultrasound gel causes fine needle aspiration artifact? A clear choice. Acta Cytologica. 2012 Feb;56(2):146-154. https://doi.org/10.1159/000335484
Royer, Mark C. ; Davidson, Darrell D. ; Dimitrov, Rosen K. ; Kuo, Connie Y. ; Kokoska, Mimi S. / Ultrasound gel causes fine needle aspiration artifact? A clear choice. In: Acta Cytologica. 2012 ; Vol. 56, No. 2. pp. 146-154.
@article{0dc8d388dc444cf5ab3bce45371570d7,
title = "Ultrasound gel causes fine needle aspiration artifact? A clear choice",
abstract = "Objectives: Ultrasound-guided fine needle aspiration (FNA) is a commonly employed tool in cytopathologic practice. Artifacts resulting in misinterpretation of specimens have been noted with various ultrasound gel media. Our purpose was to perform a prospective human cadaveric study of this phenomenon to identify a low-cost solution that eliminates the artifact. Study Design: Three separate ultrasound-guided FNAs were performed on the thyroid and parotid glands in situ of a fresh human cadaver using three different types of ultrasound gel media. Slides were prepared in standard fashion (Quik-Diff and Papanicolaou stains). Two cytopathologists subsequently analyzed the slides for the presence of any artifact interfering with their ability to visualize and interpret the cellular aspirate material. Results: Two of the three gel media revealed significant artifacts mimicking apoptosis, necrosis or colloid, making it difficult to visualize the cellular components and differentiate the artifact from the thyroid colloid. One gel medium did not show any significant artifact, and there was no discernable difference in its quality with regard to the ultrasound image during FNA procedures. Conclusions: Ultrasound gels can be associated with a significant artifact in FNA specimens. To eliminate this artifact, which may alter the adequacy, diagnosis or cytologic appearance, we confirm a specific gel type that is useful for ultrasound-guided FNAs.",
keywords = "Artifact, Fine needle aspiration, Parotid gland, Thyroid gland, Ultrasound gel",
author = "Royer, {Mark C.} and Davidson, {Darrell D.} and Dimitrov, {Rosen K.} and Kuo, {Connie Y.} and Kokoska, {Mimi S.}",
year = "2012",
month = "2",
doi = "10.1159/000335484",
language = "English (US)",
volume = "56",
pages = "146--154",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "2",

}

TY - JOUR

T1 - Ultrasound gel causes fine needle aspiration artifact? A clear choice

AU - Royer, Mark C.

AU - Davidson, Darrell D.

AU - Dimitrov, Rosen K.

AU - Kuo, Connie Y.

AU - Kokoska, Mimi S.

PY - 2012/2

Y1 - 2012/2

N2 - Objectives: Ultrasound-guided fine needle aspiration (FNA) is a commonly employed tool in cytopathologic practice. Artifacts resulting in misinterpretation of specimens have been noted with various ultrasound gel media. Our purpose was to perform a prospective human cadaveric study of this phenomenon to identify a low-cost solution that eliminates the artifact. Study Design: Three separate ultrasound-guided FNAs were performed on the thyroid and parotid glands in situ of a fresh human cadaver using three different types of ultrasound gel media. Slides were prepared in standard fashion (Quik-Diff and Papanicolaou stains). Two cytopathologists subsequently analyzed the slides for the presence of any artifact interfering with their ability to visualize and interpret the cellular aspirate material. Results: Two of the three gel media revealed significant artifacts mimicking apoptosis, necrosis or colloid, making it difficult to visualize the cellular components and differentiate the artifact from the thyroid colloid. One gel medium did not show any significant artifact, and there was no discernable difference in its quality with regard to the ultrasound image during FNA procedures. Conclusions: Ultrasound gels can be associated with a significant artifact in FNA specimens. To eliminate this artifact, which may alter the adequacy, diagnosis or cytologic appearance, we confirm a specific gel type that is useful for ultrasound-guided FNAs.

AB - Objectives: Ultrasound-guided fine needle aspiration (FNA) is a commonly employed tool in cytopathologic practice. Artifacts resulting in misinterpretation of specimens have been noted with various ultrasound gel media. Our purpose was to perform a prospective human cadaveric study of this phenomenon to identify a low-cost solution that eliminates the artifact. Study Design: Three separate ultrasound-guided FNAs were performed on the thyroid and parotid glands in situ of a fresh human cadaver using three different types of ultrasound gel media. Slides were prepared in standard fashion (Quik-Diff and Papanicolaou stains). Two cytopathologists subsequently analyzed the slides for the presence of any artifact interfering with their ability to visualize and interpret the cellular aspirate material. Results: Two of the three gel media revealed significant artifacts mimicking apoptosis, necrosis or colloid, making it difficult to visualize the cellular components and differentiate the artifact from the thyroid colloid. One gel medium did not show any significant artifact, and there was no discernable difference in its quality with regard to the ultrasound image during FNA procedures. Conclusions: Ultrasound gels can be associated with a significant artifact in FNA specimens. To eliminate this artifact, which may alter the adequacy, diagnosis or cytologic appearance, we confirm a specific gel type that is useful for ultrasound-guided FNAs.

KW - Artifact

KW - Fine needle aspiration

KW - Parotid gland

KW - Thyroid gland

KW - Ultrasound gel

UR - http://www.scopus.com/inward/record.url?scp=84857879147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857879147&partnerID=8YFLogxK

U2 - 10.1159/000335484

DO - 10.1159/000335484

M3 - Article

C2 - 22378076

AN - SCOPUS:84857879147

VL - 56

SP - 146

EP - 154

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 2

ER -