Ultrasound-guided localized detection of cavitation during lithotripsy in pig kidney in vivo

Oleg A. Sapozhnikov, Michael R. Bailey, Lawrence A. Crum, Nathan A. Miller, Robin O. Cleveland, Yuri A. Pishchalnikov, Irina V. Pishchalnikova, James A. McAteer, Bret A. Connors, Philip M. Blomgren, Andrew Evan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

It is supposed that inertial cavitation plays a significant role in tissue damage during extracorporeal shock wave lithotripsy (ESWL). In this work we attempted to detect cavitation in tissue. In vivo experiments with pigs were conducted in a Dornier HM3 electrohydraulic lithotripter. Kidney alignment was made using fluoroscopy and B-mode ultrasound. Cavitation was detected by a dual passive cavitation detection (DPCD) system consisting of two confocal spherical bowl PZT transducers (1.15MHz, focal length 10 cm, radius 10 cm). [1] An ultrasound scanhead was placed between the transducers, and hyperechoic spots in the image indicated pockets of bubbles during ESWL. A coincidence-detection algorithm and the confocal transducers made it possible to localize cavitation to within a 4 mm diameter region. The signals from both the collecting system and kidney tissue were recorded. The targeting of the DPCD focus was confirmed by using the DPCD transducers as high intensity focused ultrasound (HIFU) sources at HIFU durations below the lesion formation threshold. In this HIFU regime, a bright spot appears in the B-mode image indicating the position of the DPCD focus. [2] In this way we could confirm that refraction and scattering in tissue did not cause a misalignment. The tissue region interrogated was also marked with a lesion produced by HIFU. Clear cavitation signals were detected from the collecting system and from pools of blood that formed near the kidney capsule and weak signals were recorded from tissue during the ESWL treatment.

Original languageEnglish (US)
Title of host publicationProceedings of the IEEE Ultrasonics Symposium
Pages1347-1350
Number of pages4
Volume2
StatePublished - 2001
Externally publishedYes
Event2001 Ultrasonics Symposium - Atlanta, GA, United States
Duration: Oct 6 2001Oct 10 2001

Other

Other2001 Ultrasonics Symposium
CountryUnited States
CityAtlanta, GA
Period10/6/0110/10/01

Fingerprint

Cavitation
Ultrasonics
Tissue
Transducers
Shock waves
Refraction
Blood
Scattering

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sapozhnikov, O. A., Bailey, M. R., Crum, L. A., Miller, N. A., Cleveland, R. O., Pishchalnikov, Y. A., ... Evan, A. (2001). Ultrasound-guided localized detection of cavitation during lithotripsy in pig kidney in vivo. In Proceedings of the IEEE Ultrasonics Symposium (Vol. 2, pp. 1347-1350)

Ultrasound-guided localized detection of cavitation during lithotripsy in pig kidney in vivo. / Sapozhnikov, Oleg A.; Bailey, Michael R.; Crum, Lawrence A.; Miller, Nathan A.; Cleveland, Robin O.; Pishchalnikov, Yuri A.; Pishchalnikova, Irina V.; McAteer, James A.; Connors, Bret A.; Blomgren, Philip M.; Evan, Andrew.

Proceedings of the IEEE Ultrasonics Symposium. Vol. 2 2001. p. 1347-1350.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sapozhnikov, OA, Bailey, MR, Crum, LA, Miller, NA, Cleveland, RO, Pishchalnikov, YA, Pishchalnikova, IV, McAteer, JA, Connors, BA, Blomgren, PM & Evan, A 2001, Ultrasound-guided localized detection of cavitation during lithotripsy in pig kidney in vivo. in Proceedings of the IEEE Ultrasonics Symposium. vol. 2, pp. 1347-1350, 2001 Ultrasonics Symposium, Atlanta, GA, United States, 10/6/01.
Sapozhnikov OA, Bailey MR, Crum LA, Miller NA, Cleveland RO, Pishchalnikov YA et al. Ultrasound-guided localized detection of cavitation during lithotripsy in pig kidney in vivo. In Proceedings of the IEEE Ultrasonics Symposium. Vol. 2. 2001. p. 1347-1350
Sapozhnikov, Oleg A. ; Bailey, Michael R. ; Crum, Lawrence A. ; Miller, Nathan A. ; Cleveland, Robin O. ; Pishchalnikov, Yuri A. ; Pishchalnikova, Irina V. ; McAteer, James A. ; Connors, Bret A. ; Blomgren, Philip M. ; Evan, Andrew. / Ultrasound-guided localized detection of cavitation during lithotripsy in pig kidney in vivo. Proceedings of the IEEE Ultrasonics Symposium. Vol. 2 2001. pp. 1347-1350
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