Umbilical cord blood hematopoietic stem and repopulating cells in human clinical transplantation

H. E. Broxmeyer, J. Kurtzberg, E. Gluckman, A. D. Auerbach, G. Douglas, S. Cooper, J. H.F. Falkenburg, J. Bard, E. A. Boyse

Research output: Contribution to journalArticlepeer-review

170 Scopus citations

Abstract

This paper reviews our recent laboratory and clinical studies demonstrating the efficacious use of human umbilical cord blood for HLA-matched allogeneic sibling stem/progenitor cell transplantation in cases of Fanconi's anemia. Future implications and potential problems are discussed with regards to (a) the possibility of maternal cell contamination, (b) the broadness of applicability with regards to other diseases that might be transplanted, and whether such transplants are feasible in adults, as well as in children, and (c) the immunological reactivity of cord blood cells, and whether these cells can be used to cross histocompatibility barriers more easily than that of bone marrow from adults.

Original languageEnglish (US)
Pages (from-to)313-329
Number of pages17
JournalBlood Cells
Volume17
Issue number2
StatePublished - 1991

Keywords

  • Human umbilical cord blood
  • Stem/progenitor cells
  • Transplantation

ASJC Scopus subject areas

  • Hematology

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