Uncertain Value of Urinary Sediments in the Diagnosis of Amyloidosis

Tsuranobu Shirahama, Martha Skinner, Alan S. Cohen, Merrill D. Benson

Research output: Contribution to journalArticle

15 Scopus citations


IN their article on the appearance of amyloid fibrils in the urinary sediment of a patient with amyloidosis1 Derosena, Koss and Pirani emphasized its potential clinical, diagnostic and investigative value. This study was followed by several reports2 3 4 that in effect supported this view. Contrary to these reports and to our expectation, however, our own preliminary attempts to detect amyloid-related substances in urine by immunologic methods using antiserums to amyloid protein AA (the major and unique constituent of secondary amyloid)5 had failed. We therefore conducted a systematic study for the appearance of amyloid in urine sediments and of its clinical and.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalNew England Journal of Medicine
Issue number15
StatePublished - Oct 13 1977
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Uncertain Value of Urinary Sediments in the Diagnosis of Amyloidosis'. Together they form a unique fingerprint.

  • Cite this