Uncertain Value of Urinary Sediments in the Diagnosis of Amyloidosis

Tsuranobu Shirahama, Martha Skinner, Alan S. Cohen, Merrill D. Benson

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Abstract

IN their article on the appearance of amyloid fibrils in the urinary sediment of a patient with amyloidosis1 Derosena, Koss and Pirani emphasized its potential clinical, diagnostic and investigative value. This study was followed by several reports2 3 4 that in effect supported this view. Contrary to these reports and to our expectation, however, our own preliminary attempts to detect amyloid-related substances in urine by immunologic methods using antiserums to amyloid protein AA (the major and unique constituent of secondary amyloid)5 had failed. We therefore conducted a systematic study for the appearance of amyloid in urine sediments and of its clinical and.

Original languageEnglish (US)
Pages (from-to)821-823
Number of pages3
JournalNew England Journal of Medicine
Volume297
Issue number15
DOIs
StatePublished - Oct 13 1977

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ASJC Scopus subject areas

  • Medicine(all)

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