Unclassified hemangioma-like renal cell carcinoma

a potential diagnostic pitfall

Kanika Taneja, Sohrab Arora, Craig G. Rogers, Nilesh S. Gupta, Liang Cheng, Sean R. Williamson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recently, rare renal cell carcinomas (RCCs) have been reported to closely mimic hemangioma; however, these have been largely recognizable as clear cell RCC. Conversely, true hemangiomas of the kidney are also increasingly recognized. We report a 62-year-old woman who underwent partial nephrectomy for a hemangioma-like RCC without appreciable clear cell morphology. Immunohistochemistry revealed luminal structures that stained positively for cytokeratin, cytokeratin 7, carbonic anhydrase IX, PAX8, and high-molecular-weight keratin, admixed with a CD34-positive, CD31-positive, and ERG-positive complex network of vessels. Staining was minimal for α-methyl-acyl-coA-racemase and EMA, and absent for GATA3, HMB45, melan-A, and cathepsin K. Fluorescence in situ hybridization revealed no TFE3 or TFEB rearrangement, 3p deletion, or trisomy 7 or 17. This case adds to the spectrum of hemangioma-like RCC with differing morphology and immunophenotype. Further study will determine whether this represents a distinct entity or an unusual pattern of degenerative changes in an existing entity.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalHuman Pathology
Volume75
DOIs
StatePublished - May 1 2018

Fingerprint

Hemangioma
Renal Cell Carcinoma
Keratins
MART-1 Antigen
Cathepsin K
Keratin-7
Racemases and Epimerases
Nephrectomy
Fluorescence In Situ Hybridization
Molecular Weight
Immunohistochemistry
Staining and Labeling
Kidney

Keywords

  • Clear cell renal cell carcinoma
  • Hemangioma
  • Immunohistochemistry
  • Kidney cancer
  • Partial nephrectomy
  • Unclassified renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Unclassified hemangioma-like renal cell carcinoma : a potential diagnostic pitfall. / Taneja, Kanika; Arora, Sohrab; Rogers, Craig G.; Gupta, Nilesh S.; Cheng, Liang; Williamson, Sean R.

In: Human Pathology, Vol. 75, 01.05.2018, p. 132-136.

Research output: Contribution to journalArticle

Taneja, Kanika ; Arora, Sohrab ; Rogers, Craig G. ; Gupta, Nilesh S. ; Cheng, Liang ; Williamson, Sean R. / Unclassified hemangioma-like renal cell carcinoma : a potential diagnostic pitfall. In: Human Pathology. 2018 ; Vol. 75. pp. 132-136.
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