Unclassified hemangioma-like renal cell carcinoma: a potential diagnostic pitfall

Kanika Taneja, Sohrab Arora, Craig G. Rogers, Nilesh S. Gupta, Liang Cheng, Sean R. Williamson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Recently, rare renal cell carcinomas (RCCs) have been reported to closely mimic hemangioma; however, these have been largely recognizable as clear cell RCC. Conversely, true hemangiomas of the kidney are also increasingly recognized. We report a 62-year-old woman who underwent partial nephrectomy for a hemangioma-like RCC without appreciable clear cell morphology. Immunohistochemistry revealed luminal structures that stained positively for cytokeratin, cytokeratin 7, carbonic anhydrase IX, PAX8, and high-molecular-weight keratin, admixed with a CD34-positive, CD31-positive, and ERG-positive complex network of vessels. Staining was minimal for α-methyl-acyl-coA-racemase and EMA, and absent for GATA3, HMB45, melan-A, and cathepsin K. Fluorescence in situ hybridization revealed no TFE3 or TFEB rearrangement, 3p deletion, or trisomy 7 or 17. This case adds to the spectrum of hemangioma-like RCC with differing morphology and immunophenotype. Further study will determine whether this represents a distinct entity or an unusual pattern of degenerative changes in an existing entity.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalHuman pathology
Volume75
DOIs
StatePublished - May 2018

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Keywords

  • Clear cell renal cell carcinoma
  • Hemangioma
  • Immunohistochemistry
  • Kidney cancer
  • Partial nephrectomy
  • Unclassified renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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